TRAM2

Translocating chain-associated membrane protein 2 is a protein that in humans is encoded by the TRAM2 gene.[5][6][7]

TRAM2
Identifiers
AliasesTRAM2, translocation associated membrane protein 2
External IDsOMIM: 608485 MGI: 1924817 HomoloGene: 8183 GeneCards: TRAM2
Orthologs
SpeciesHumanMouse
Entrez

9697

170829

Ensembl

ENSG00000065308

ENSMUSG00000041779

UniProt

Q15035

Q924Z5

RefSeq (mRNA)

NM_012288

NM_177409

RefSeq (protein)

NP_036420

NP_803128

Location (UCSC)Chr 6: 52.5 – 52.58 MbChr 1: 21.07 – 21.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000065308 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000041779 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
  6. Onuchic LF, Mrug M, Lakings AL, Muecher G, Becker J, Zerres K, Avner ED, Dixit M, Somlo S, Germino GG, Guay-Woodford LM (Jan 2000). "Genomic organization of the KIAA0057 gene that encodes a TRAM-like protein and its exclusion as a polycystic kidney and hepatic disease 1 (PKHD1) candidate gene". Mamm Genome. 10 (12): 1175–8. doi:10.1007/s003359901186. PMID 10594243. S2CID 11705244.
  7. "Entrez Gene: TRAM2 translocation associated membrane protein 2".

Further reading


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