TRDMT1

TRDMT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1G55
Identifiers
Aliases	TRDMT1, DMNT2, DNMT2, MHSAIIP, PUMET, RNMT1, tRNA aspartic acid methyltransferase 1
External IDs	OMIM: 602478 MGI: 1274787 HomoloGene: 3249 GeneCards: TRDMT1
Gene location (Human)
Chr.	Chromosome 10 (human)[1]
End	17,202,054 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	13,549,479 bp[2]
RNA expression pattern
	Top expressed in
	Achilles tendon; ; ganglionic eminence; ; right uterine tube; ; monocyte; ; sural nerve; ; stromal cell of endometrium; ; corpus epididymis; ; popliteal artery; ; caput epididymis; ; thoracic aorta;
	Top expressed in
	otic placode; ; saccule; ; atrioventricular valve; ; spermatocyte; ; secondary oocyte; ; primitive streak; ; endocardial cushion; ; medial ganglionic eminence; ; superior cervical ganglion; ; iris;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; transferase activity; tRNA methyltransferase activity; RNA binding; tRNA (cytosine-5-)-methyltransferase activity;
Cellular component	cytoplasm; nucleus; nucleoplasm;
Biological process	response to amphetamine; methylation; tRNA methylation; tRNA modification; tRNA processing;
	Sources:Amigo / QuickGO
Orthologs
	1787
	13434
	ENSG00000107614
	ENSMUSG00000026723
	O14717
	O55055
NM_004412; NM_176081; NM_176083; NM_176084; NM_176085;
	NM_176086; NM_001321006; NM_001321007; NM_001351219; NM_001351220; NM_001351221; NM_001351222; NM_001351223
	NM_010067
NP_001307935; NP_001307936; NP_004403; NP_001338148; NP_001338149;
	NP_001338150; NP_001338151; NP_001338152
	NP_034197
	Wikidata
View/Edit Human	View/Edit Mouse

tRNA (cytosine-5-)-methyltransferase is an enzyme that in humans is encoded by the TRDMT1 gene.[5][6][7][8]

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a protein with similarity to DNA methyltransferases, but this protein does not display methyltransferase activity. The protein strongly binds DNA, suggesting that it may mark specific sequences in the genome. Alternative splicing results in multiple transcript variants encoding different isoforms.[8]

It has been shown that human DNMT2 does not methylate DNA but instead methylates cytosine 38 in the anticodon loop of aspartic acid transfer RNA (tRNA(Asp)).[9]

References

GRCh38: Ensembl release 89: ENSG00000107614 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000026723 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Yoder JA, Bestor TH (Mar 1998). "A candidate mammalian DNA methyltransferase related to pmt1p of fission yeast". Hum Mol Genet. 7 (2): 279–84. doi:10.1093/hmg/7.2.279. PMID 9425235.
Vilain A, Apiou F, Dutrillaux B, Malfoy B (Nov 1998). "Assignment of candidate DNA methyltransferase gene (DNMT2) to human chromosome band 10p15.1 by in situ hybridization". Cytogenet Cell Genet. 82 (1–2): 120. doi:10.1159/000015083. PMID 9763678. S2CID 46803768.
Goll MG, Kirpekar F, Maggert KA, Yoder JA, Hsieh CL, Zhang X, Golic KG, Jacobsen SE, Bestor TH (Jan 2006). "Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2". Science. 311 (5759): 395–8. Bibcode:2006Sci...311..395G. doi:10.1126/science.1120976. PMID 16424344. S2CID 39089541.
"Entrez Gene: TRDMT1 tRNA aspartic acid methyltransferase 1".
Goll MG, Kirpekar F, Maggert KA, et al. (2006). "Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2". Science. 311 (5759): 395–8. Bibcode:2006Sci...311..395G. doi:10.1126/science.1120976. PMID 16424344. S2CID 39089541.

Okano M, Xie S, Li E (1998). "Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells". Nucleic Acids Res. 26 (11): 2536–40. doi:10.1093/nar/26.11.2536. PMC 147598. PMID 9592134.
Van den Wyngaert I, Sprengel J, Kass SU, Luyten WH (1998). "Cloning and analysis of a novel human putative DNA methyltransferase". FEBS Lett. 426 (2): 283–9. doi:10.1016/S0014-5793(98)00362-7. PMID 9599025. S2CID 7887099.
Dong A, Yoder JA, Zhang X, et al. (2001). "Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA". Nucleic Acids Res. 29 (2): 439–48. doi:10.1093/nar/29.2.439. PMC 29660. PMID 11139614.
Franchina M, Hooper J, Kay PH (2001). "Five novel alternatively spliced transcripts of DNA (cytosine-5) methyltransferase 2 in human peripheral blood leukocytes". Int. J. Biochem. Cell Biol. 33 (11): 1104–15. doi:10.1016/S1357-2725(01)00074-7. PMID 11551826.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hermann A, Schmitt S, Jeltsch A (2003). "The human Dnmt2 has residual DNA-(cytosine-C5) methyltransferase activity". J. Biol. Chem. 278 (34): 31717–21. doi:10.1074/jbc.M305448200. PMID 12794065.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Xiong Y, Dowdy SC, Xue A, et al. (2005). "Opposite alterations of DNA methyltransferase gene expression in endometrioid and serous endometrial cancers". Gynecol. Oncol. 96 (3): 601–9. doi:10.1016/j.ygyno.2004.11.047. PMID 15721400.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Pang ST, Weng WH, Flores-Morales A, et al. (2006). "Cytogenetic and expression profiles associated with transformation to androgen-resistant prostate cancer". Prostate. 66 (2): 157–72. doi:10.1002/pros.20328. PMID 16173030. S2CID 26023143.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000107614 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026723 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9425235-5] Yoder JA, Bestor TH (Mar 1998). "A candidate mammalian DNA methyltransferase related to pmt1p of fission yeast". Hum Mol Genet. 7 (2): 279–84. doi:10.1093/hmg/7.2.279. PMID 9425235.

[pmid9763678-6] Vilain A, Apiou F, Dutrillaux B, Malfoy B (Nov 1998). "Assignment of candidate DNA methyltransferase gene (DNMT2) to human chromosome band 10p15.1 by in situ hybridization". Cytogenet Cell Genet. 82 (1–2): 120. doi:10.1159/000015083. PMID 9763678. S2CID 46803768.

[pmid16424344-7] Goll MG, Kirpekar F, Maggert KA, Yoder JA, Hsieh CL, Zhang X, Golic KG, Jacobsen SE, Bestor TH (Jan 2006). "Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2". Science. 311 (5759): 395–8. Bibcode:2006Sci...311..395G. doi:10.1126/science.1120976. PMID 16424344. S2CID 39089541.

[entrez-8] "Entrez Gene: TRDMT1 tRNA aspartic acid methyltransferase 1".

[9] Goll MG, Kirpekar F, Maggert KA, et al. (2006). "Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2". Science. 311 (5759): 395–8. Bibcode:2006Sci...311..395G. doi:10.1126/science.1120976. PMID 16424344. S2CID 39089541.

TRDMT1

References

Further reading