TRIM29

Tripartite motif-containing protein 29 is a protein that in humans is encoded by the TRIM29 gene.[5][6]

TRIM29
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTRIM29, ATDC, tripartite motif containing 29
External IDsOMIM: 610658 MGI: 1919419 HomoloGene: 8100 GeneCards: TRIM29
Orthologs
SpeciesHumanMouse
Entrez

23650

72169

Ensembl

ENSG00000137699

ENSMUSG00000032013

UniProt

Q14134

Q8R2Q0

RefSeq (mRNA)

NM_012101
NM_058193
NM_001330382

NM_023655

RefSeq (protein)

NP_001317311
NP_036233

NP_076144

Location (UCSC)Chr 11: 120.11 – 120.19 MbChr 9: 43.22 – 43.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia–telangiectasia phenotype.[6]

Interactions

TRIM29 has been shown to interact with TRIM23[5] and GCC1.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000137699 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000032013 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
  6. "Entrez Gene: TRIM29 tripartite motif-containing 29".
  7. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.