TRIM45

tripartite motif containing 45, also known as TRIM45, is a human gene.[5]

TRIM45
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTRIM45, RNF99, tripartite motif containing 45
External IDsOMIM: 609318 MGI: 1918187 HomoloGene: 11865 GeneCards: TRIM45
Orthologs
SpeciesHumanMouse
Entrez

80263

229644

Ensembl

ENSG00000134253

ENSMUSG00000033233

UniProt

Q9H8W5

Q6PFY8

RefSeq (mRNA)

NM_001145635
NM_025188

NM_001165952
NM_001165953
NM_194343

RefSeq (protein)

NP_001139107
NP_079464

NP_001159424
NP_001159425
NP_919324

Location (UCSC)Chr 1: 117.11 – 117.12 MbChr 3: 100.83 – 100.84 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the tripartite motif family. The encoded protein may function as a [transcriptional repressor of the mitogen-activated protein kinase pathway. Alternatively spliced transcript variants have been described.[5]

Model organisms

Model organisms have been used in the study of TRIM45 function. A conditional knockout mouse line, called Trim45tm1a(KOMP)Wtsi[11][12] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[13][14][15]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[9][16] Twenty six tests were carried out on mutant mice and three significant abnormalities were observed.[9] No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; males had increased circulating magnesium levels while animals of both sex displayed increased bone strength.[9]

References
  1. GRCh38: Ensembl release 89: ENSG00000134253 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000033233 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: tripartite motif containing 45". Retrieved 2011-08-30.
  6. "Clinical chemistry data for Trim45". Wellcome Trust Sanger Institute.
  7. "Salmonella infection data for Trim45". Wellcome Trust Sanger Institute.
  8. "Citrobacter infection data for Trim45". Wellcome Trust Sanger Institute.
  9. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  10. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  11. "International Knockout Mouse Consortium".
  12. "Mouse Genome Informatics".
  13. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  14. Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  15. Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  16. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading
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