TRIM6

Tripartite motif-containing protein 6 is a protein that in humans is encoded by the TRIM6 gene.[5][6]

TRIM6
Identifiers
AliasesTRIM6, RNF89, tripartite motif containing 6
External IDsOMIM: 607564 MGI: 2137352 HomoloGene: 14381 GeneCards: TRIM6
Orthologs
SpeciesHumanMouse
Entrez

117854

94088

Ensembl

ENSG00000121236

ENSMUSG00000072244

UniProt

Q9C030

Q8BGE7

RefSeq (mRNA)

NM_058166
NM_001003818
NM_001198644
NM_001198645

NM_001013616

RefSeq (protein)

NP_001003818
NP_001185573
NP_001185574
NP_477514

NP_001013637

Location (UCSC)Chr 11: 5.6 – 5.61 MbChr 7: 103.87 – 103.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.

The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. A read-through transcript transcribed from this gene and TRIM34 has been observed.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000121236 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000072244 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
  6. "Entrez Gene: TRIM6 tripartite motif-containing 6".

Further reading

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