TRIM69
Tripartite motif containing 69 is a protein that in humans is encoded by the TRIM69 gene. [5]
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| Aliases | TRIM69, HSD-34, HSD34, RNF36, Trif, tripartite motif containing 69 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 616017 MGI: 1918178 HomoloGene: 18827 GeneCards: TRIM69 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.
References
- ENSG00000185880 GRCh38: Ensembl release 89: ENSG00000278211, ENSG00000185880 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000033368 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: Tripartite motif containing 69". Retrieved 2016-02-16.
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human E3 ubiquitin-protein ligase TRIM69
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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