TRIM9

Tripartite motif-containing protein 9 is a protein that in humans is encoded by the TRIM9 gene.[5][6][7]

TRIM9
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTRIM9, RNF91, SPRING, tripartite motif containing 9
External IDsOMIM: 606555 MGI: 2137354 HomoloGene: 9045 GeneCards: TRIM9
Orthologs
SpeciesHumanMouse
Entrez

114088

94090

Ensembl

ENSG00000100505

ENSMUSG00000021071

UniProt

Q9C026

Q8C7M3

RefSeq (mRNA)

NM_015163
NM_052978

RefSeq (protein)

NP_055978
NP_443210

Location (UCSC)Chr 14: 50.98 – 51.1 MbChr 12: 70.29 – 70.39 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternate splicing of this gene generates two transcript variants encoding different isoforms.[7]

Interactions

TRIM9 has been shown to interact with SNAP-25.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000100505 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000021071 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
  6. Li Y, Chin LS, Weigel C, Li L (Oct 2001). "Spring, a novel RING finger protein that regulates synaptic vesicle exocytosis". J Biol Chem. 276 (44): 40824–33. doi:10.1074/jbc.M106141200. PMID 11524423.
  7. "Entrez Gene: TRIM9 tripartite motif-containing 9".

Further reading


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.