TRIT1

tRNA isopentenyltransferase, mitochondrial is an enzyme that in humans is encoded by the TRIT1 gene.

TRIT1
Identifiers
AliasesTRIT1, IPT, MOD5, GRO1, IPPT, IPTase, hGRO1, tRNA isopentenyltransferase 1, COXPD35
External IDsOMIM: 617840 MGI: 1914216 HomoloGene: 7010 GeneCards: TRIT1
Orthologs
SpeciesHumanMouse
Entrez

54802

66966

Ensembl

ENSG00000043514

ENSMUSG00000028653

UniProt

Q9H3H1

Q80UN9

RefSeq (mRNA)

NM_001312691
NM_001312692
NM_017646

NM_025873

RefSeq (protein)

NP_001299620
NP_001299621
NP_060116

NP_080149

Location (UCSC)Chr 1: 39.84 – 39.88 MbChr 4: 122.91 – 122.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

It catalyzes the addition of an isopentenyl group from dimethylallyl diphosphate (DMAPP) onto adenosine residue 37 of certain tRNA molecules.[5][6][7]



References

  1. GRCh38: Ensembl release 89: ENSG00000043514 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028653 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Golovko A, Hjalm G, Sitbon F, Nicander B (Jan 2001). "Cloning of a human tRNA isopentenyl transferase". Gene. 258 (1–2): 85–93. doi:10.1016/S0378-1119(00)00421-2. PMID 11111046.
  6. Spinola M, Galvan A, Pignatiello C, Conti B, Pastorino U, Nicander B, Paroni R, Dragani TA (Aug 2005). "Identification and functional characterization of the candidate tumor suppressor gene TRIT1 in human lung cancer". Oncogene. 24 (35): 5502–9. doi:10.1038/sj.onc.1208687. PMID 15870694.
  7. "Entrez Gene: TRIT1 tRNA isopentenyltransferase 1".

Further reading


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