TRIT1

TRIT1
Identifiers
Aliases	TRIT1, IPT, MOD5, GRO1, IPPT, IPTase, hGRO1, tRNA isopentenyltransferase 1, COXPD35
External IDs	OMIM: 617840 MGI: 1914216 HomoloGene: 7010 GeneCards: TRIT1
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	39,883,511 bp[1]
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)[2]
End	122,948,742 bp[2]
RNA expression pattern
	Top expressed in
	oocyte; ; body of pancreas; ; vagina; ; skin of abdomen; ; right uterine tube; ; secondary oocyte; ; left lobe of thyroid gland; ; prostate; ; right lobe of thyroid gland; ; cerebellar hemisphere;
	Top expressed in
	saccule; ; medullary collecting duct; ; renal corpuscle; ; otic placode; ; lacrimal gland; ; hair follicle; ; cumulus cell; ; fossa; ; condyle; ; brown adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; ATP binding; metal ion binding; tRNA dimethylallyltransferase activity; nucleic acid binding; zinc ion binding;
Cellular component	cytoplasm; mitochondrial matrix; mitochondrion; cellular component;
Biological process	mitochondrial tRNA modification; tRNA processing; tRNA modification;
	Sources:Amigo / QuickGO
Orthologs
	54802
	66966
	ENSG00000043514
	ENSMUSG00000028653
	Q9H3H1
	Q80UN9
	NM_001312691; NM_001312692; NM_017646
	NM_025873
	NP_001299620; NP_001299621; NP_060116
	NP_080149
	Wikidata
View/Edit Human	View/Edit Mouse

tRNA isopentenyltransferase, mitochondrial is an enzyme that in humans is encoded by the TRIT1 gene.

It catalyzes the addition of an isopentenyl group from dimethylallyl diphosphate (DMAPP) onto adenosine residue 37 of certain tRNA molecules.[5][6][7]

References

GRCh38: Ensembl release 89: ENSG00000043514 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000028653 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Golovko A, Hjalm G, Sitbon F, Nicander B (Jan 2001). "Cloning of a human tRNA isopentenyl transferase". Gene. 258 (1–2): 85–93. doi:10.1016/S0378-1119(00)00421-2. PMID 11111046.
Spinola M, Galvan A, Pignatiello C, Conti B, Pastorino U, Nicander B, Paroni R, Dragani TA (Aug 2005). "Identification and functional characterization of the candidate tumor suppressor gene TRIT1 in human lung cancer". Oncogene. 24 (35): 5502–9. doi:10.1038/sj.onc.1208687. PMID 15870694.
"Entrez Gene: TRIT1 tRNA isopentenyltransferase 1".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Lemieux J, Lakowski B, Webb A, et al. (2002). "Regulation of physiological rates in Caenorhabditis elegans by a tRNA-modifying enzyme in the mitochondria". Genetics. 159 (1): 147–57. doi:10.1093/genetics/159.1.147. PMC 1461807. PMID 11560893.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Spinola M, Falvella FS, Galvan A, et al. (2007). "Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients' survival" (PDF). Lung Cancer. 55 (3): 271–7. doi:10.1016/j.lungcan.2006.10.023. hdl:2434/25016. PMID 17145094.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000043514 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028653 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11111046-5] Golovko A, Hjalm G, Sitbon F, Nicander B (Jan 2001). "Cloning of a human tRNA isopentenyl transferase". Gene. 258 (1–2): 85–93. doi:10.1016/S0378-1119(00)00421-2. PMID 11111046.

[pmid15870694-6] Spinola M, Galvan A, Pignatiello C, Conti B, Pastorino U, Nicander B, Paroni R, Dragani TA (Aug 2005). "Identification and functional characterization of the candidate tumor suppressor gene TRIT1 in human lung cancer". Oncogene. 24 (35): 5502–9. doi:10.1038/sj.onc.1208687. PMID 15870694.

[entrez-7] "Entrez Gene: TRIT1 tRNA isopentenyltransferase 1".

TRIT1

References

Further reading