TRNA:m4X modification enzyme
TRNA:m4X modification enzyme (EC 2.1.1.225, TRM13, Trm13p, tRNA:Xm4 modification enzyme) is an enzyme with systematic name S-adenosyl-L-methionine:tRNAPro/His/Gly(GCC) (cytidine/adenosine4-2'-O)-methyltransferase.[1] This enzyme catalyses the following chemical reaction
- (1) S-adenosyl-L-methionine + cytidine4 in tRNAPro S-adenosyl-L-homocysteine + 2'-O-methylcytidine4 in tRNAPro
- (2) S-adenosyl-L-methionine + cytidine4 in tRNAGly(GCC) S-adenosyl-L-homocysteine + 2'-O-methylcytidine4 in tRNAGly(GCC)
- (3) S-adenosyl-L-methionine + adenosine4 in tRNAHis S-adenosyl-L-homocysteine + 2'-O-methyladenosine4 in tRNAHis
| TRNA:m4X modification enzyme | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.225 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The enzyme from Saccharomyces cerevisiae 2'-O-methylates cytidine4 in tRNAPro and tRNAGly(GCC), and adenosine4 in tRNAHis.
References
- Wilkinson ML, Crary SM, Jackman JE, Grayhack EJ, Phizicky EM (March 2007). "The 2'-O-methyltransferase responsible for modification of yeast tRNA at position 4". RNA. 13 (3): 404–13. doi:10.1261/rna.399607. PMC 1800514. PMID 17242307.
External links
- TRNA:m4X+modification+enzyme at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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