tRNA-queuosine beta-mannosyltransferase

In enzymology, a tRNA-queuosine beta-mannosyltransferase (EC 2.4.1.110) is an enzyme that catalyzes the chemical reaction

GDP-mannose + tRNAAsp-queuosine GDP + tRNAAsp-O-5"-beta-D-mannosylqueuosine
tRNA-queuosine beta-mannosyltransferase
Identifiers
EC no.2.4.1.110
CAS no.9055-06-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Thus, the two substrates of this enzyme are GDP-mannose and tRNAAsp-queuosine, whereas its two products are GDP and tRNAAsp-O-5''-beta-D-mannosylqueuosine.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-mannose:tRNAAsp-queuosine O-5"-beta-D-mannosyltransferase.

References

    • Okada N, Nishimura S (1977). "Enzymatic synthesis of Q nucleoside containing mannose in the anticodon of tRNA: isolation of a novel mannosyltransferase from a cell-free extract of rat liver". Nucleic Acids Res. 4 (8): 2931–8. doi:10.1093/nar/4.8.2931. PMC 342620. PMID 20603.


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