TRNAMet cytidine acetyltransferase

TRNAMet cytidine acetyltransferase (EC 2.3.1.193, YpfI, TmcA) is an enzyme with systematic name acetyl-CoA:(elongator tRNAMet)-cytidine34 N4-acetyltransferase (ATP-hydrolysing).[1][2] This enzyme catalyses the following chemical reaction

[elongator tRNAMet]-cytidine34 + ATP + acetyl-CoA CoA + [elongator tRNAMet]-N4-acetylcytidine34 + ADP + phosphate
TRNAMet cytidine acetyltransferase
Identifiers
EC no.2.3.1.193
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

The enzyme acetylates the wobble base C34 of the CAU anticodon of elongation-specific tRNAMet.

References

  1. Ikeuchi Y, Kitahara K, Suzuki T (August 2008). "The RNA acetyltransferase driven by ATP hydrolysis synthesizes N4-acetylcytidine of tRNA anticodon". The EMBO Journal. 27 (16): 2194–203. doi:10.1038/emboj.2008.154. PMC 2500205. PMID 18668122.
  2. Chimnaronk S, Suzuki T, Manita T, Ikeuchi Y, Yao M, Suzuki T, Tanaka I (May 2009). "RNA helicase module in an acetyltransferase that modifies a specific tRNA anticodon". The EMBO Journal. 28 (9): 1362–73. doi:10.1038/emboj.2009.69. PMC 2683049. PMID 19322199.
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