TRNA (adenine58-N1)-methyltransferase

TRNA (adenine58-N1)-methyltransferase (EC 2.1.1.220, tRNA m1A58 methyltransferase, tRNA (m1A58) methyltransferase, TrmI, tRNA (m1A58) Mtase, Rv2118cp, Gcd10p-Gcd14p, Trm61p-Trm6p) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (adenine58-N1)-methyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + adenine58 in tRNA S-adenosyl-L-homocysteine + N1-methyladenine58 in tRNA
TRNA (adenine58-N1)-methyltransferase
Identifiers
EC no.2.1.1.220
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

The enzyme specifically methylates adenine58 in tRNA.

References

  1. Droogmans L, Roovers M, Bujnicki JM, Tricot C, Hartsch T, Stalon V, Grosjean H (April 2003). "Cloning and characterization of tRNA (m1A58) methyltransferase (TrmI) from Thermus thermophilus HB27, a protein required for cell growth at extreme temperatures". Nucleic Acids Research. 31 (8): 2148–56. doi:10.1093/nar/gkg314. PMC 153742. PMID 12682365.
  2. Varshney U, Ramesh V, Madabushi A, Gaur R, Subramanya HS, RajBhandary UL (2004). "Mycobacterium tuberculosis Rv2118c codes for a single-component homotetrameric m1A58 tRNA methyltransferase". Nucleic Acids Research. 32 (3): 1018–27. doi:10.1093/nar/gkh207. PMC 373377. PMID 14960715.
  3. Anderson J, Phan L, Hinnebusch AG (May 2000). "The Gcd10p/Gcd14p complex is the essential two-subunit tRNA(1-methyladenosine) methyltransferase of Saccharomyces cerevisiae". Proceedings of the National Academy of Sciences of the United States of America. 97 (10): 5173–8. doi:10.1073/pnas.090102597. PMC 25801. PMID 10779558.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.