TRNA (cytosine34-C5)-methyltransferase
TRNA (cytosine34-C5)-methyltransferase (EC 2.1.1.203, hTrm4 Mtase, hTrm4 methyltransferase, hTrm4 (gene), tRNA:m5C-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (cytosine34-C5)-methyltransferase.[1] This enzyme catalyses the following chemical reaction
- S-adenosyl-L-methionine + cytosine34 in tRNA precursor S-adenosyl-L-homocysteine + 5-methylcytosine34 in tRNA precursor
| TRNA (cytosine34-C5)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.203 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The human enzyme is specific for C5-methylation of cytosine34 in tRNA precursors.
References
- Brzezicha B, Schmidt M, Makalowska I, Jarmolowski A, Pienkowska J, Szweykowska-Kulinska Z (2006). "Identification of human tRNA:m5C methyltransferase catalysing intron-dependent m5C formation in the first position of the anticodon of the pre-tRNA Leu (CAA)". Nucleic Acids Research. 34 (20): 6034–43. doi:10.1093/nar/gkl765. PMC 1635329. PMID 17071714.
External links
- TRNA+(cytosine34-C5)-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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