TRNA (guanine26-N2/guanine27-N2)-dimethyltransferase

TRNA (guanine26-N2/guanine27-N2)-dimethyltransferase (EC 2.1.1.215, Trm1, tRNA (N2,N2-guanine)-dimethyltransferase, tRNA (m2(2G26) methyltransferase, Trm1[tRNA (m2(2)G26) methyltransferase]) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase.[1] This enzyme catalyses the following chemical reaction

4 S-adenosyl-L-methionine + guanine26/guanine27 in tRNA 4 S-adenosyl-L-homocysteine + N2-dimethylguanine26/N2-dimethylguanine27 in tRNA
TRNA (guanine26-N2/guanine27-N2)-dimethyltransferase
Identifiers
EC no.2.1.1.215
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

The enzyme from Aquifex aeolicus is similar to the TRM1 methyltransferases of archaea and eukarya.

References

  1. Awai T, Kimura S, Tomikawa C, Ochi A, Bessho Y, Yokoyama S, Ohno S, Nishikawa K, Yokogawa T, Suzuki T, Hori H (July 2009). "Aquifex aeolicus tRNA (N2,N2-guanine)-dimethyltransferase (Trm1) catalyzes transfer of methyl groups not only to guanine 26 but also to guanine 27 in tRNA". The Journal of Biological Chemistry. 284 (31): 20467–78. doi:10.1074/jbc.m109.020024. PMC 2742811. PMID 19491098.
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