TRNA (guanine9-N1)-methyltransferase

TRNA (guanine9-N1)-methyltransferase (EC 2.1.1.221, Trm10p, tRNA(m1G9/m1A9)-methyltransferase, tRNA(m1G9/m1A9)MTase, tRNA (guanine-N(1)-)-methyltransferase, tRNA m1G9-methyltransferase, tRNA m1G9 MTase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine9-N1)-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanine9 in tRNA S-adenosyl-L-homocysteine + N1-methylguanine9 in tRNA
TRNA (guanine9-N1)-methyltransferase
Identifiers
EC no.2.1.1.221
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

The enzyme from Saccharomyces cerevisiae specifically methylates guanine9.

References

  1. Kempenaers M, Roovers M, Oudjama Y, Tkaczuk KL, Bujnicki JM, Droogmans L (October 2010). "New archaeal methyltransferases forming 1-methyladenosine or 1-methyladenosine and 1-methylguanosine at position 9 of tRNA". Nucleic Acids Research. 38 (19): 6533–43. doi:10.1093/nar/gkq451. PMC 2965216. PMID 20525789.
  2. Jackman JE, Montange RK, Malik HS, Phizicky EM (May 2003). "Identification of the yeast gene encoding the tRNA m1G methyltransferase responsible for modification at position 9". RNA. 9 (5): 574–85. doi:10.1261/rna.5070303. PMC 1370423. PMID 12702816.
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