TTI2
TELO2 interacting protein 2 is a protein that in humans is encoded by the TTI2 gene. [5]
| TTI2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | TTI2, C8orf41, MRT39, TELO2 interacting protein 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 614426 MGI: 2384576 HomoloGene: 11836 GeneCards: TTI2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
This gene encodes a regulator of the DNA damage response. The protein is a component of the Triple T complex (TTT) which also includes telomere length regulation protein and TELO2 interacting protein 1.
The TTT complex is involved in cellular resistance to DNA damage stresses and may act as a regulator of phosphoinositide-3-kinase-related protein kinase (PIKK) abundance.
References
- GRCh38: Ensembl release 89: ENSG00000129696 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000031577 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: TELO2 interacting protein 2". Retrieved 2016-12-14.
Further reading
- Hurov KE, Cotta-Ramusino C, Elledge SJ (2010). "A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability". Genes Dev. 24 (17): 1939–50. doi:10.1101/gad.1934210. PMC 2932975. PMID 20810650.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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