Tubulin beta-4B chain

TUBB4B
Identifiers
Aliases	TUBB4B, Beta2, TUBB2, TUBB2C, tubulin beta 4B class IVb, LCAEOD
External IDs	OMIM: 602660 MGI: 1915472 HomoloGene: 68504 GeneCards: TUBB4B
Gene location (Human)
Chr.	Chromosome 9 (human)[1]
End	137,243,707 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	25,114,714 bp[2]
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; right uterine tube; ; spinal ganglia; ; orbitofrontal cortex; ; Brodmann area 46; ; superior vestibular nucleus; ; postcentral gyrus; ; entorhinal cortex; ; pons; ; gums;
	Top expressed in
	spermatid; ; testicle; ; spermatocyte; ; secondary oocyte; ; hypothalamus; ; esophagus; ; bone marrow; ; mirror; ; lip; ; zone of skin;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; unfolded protein binding; GTP binding; structural constituent of cytoskeleton; GTPase activity; double-stranded RNA binding; MHC class I protein binding;
Cellular component	cytoplasm; extracellular vesicle; cytosol; myelin sheath; microtubule; cytoskeleton; extracellular exosome; nucleus; extracellular matrix; extracellular region; microtubule cytoskeleton; azurophil granule lumen;
Biological process	G2/M transition of mitotic cell cycle; microtubule-based process; natural killer cell mediated cytotoxicity; cytoskeleton organization; neutrophil degranulation; ciliary basal body-plasma membrane docking; regulation of G2/M transition of mitotic cell cycle; microtubule cytoskeleton organization; mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	10383
	227613
	ENSG00000188229
	ENSMUSG00000036752
	P68371
	P68372
	NM_006088
	NM_146116
	NP_006079
	NP_666228
	Wikidata
View/Edit Human	View/Edit Mouse

Tubulin beta-4B chain formerly known as tubulin beta-2C chain is a protein that in humans is encoded by the TUBB4B gene.[5][6]

References

GRCh38: Ensembl release 89: ENSG00000188229 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000036752 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Lewis SA, Gilmartin ME, Hall JL, Cowan NJ (Jul 1985). "Three expressed sequences within the human beta-tubulin multigene family each define a distinct isotype". J Mol Biol. 182 (1): 11–20. doi:10.1016/0022-2836(85)90023-3. PMID 3999141.
"Entrez Gene: TUBB2C tubulin, beta 2C".

Burgoyne RD, Cambray-Deakin MA, Lewis SA, et al. (1989). "Differential distribution of beta-tubulin isotypes in cerebellum". EMBO J. 7 (8): 2311–9. doi:10.1002/j.1460-2075.1988.tb03074.x. PMC 457095. PMID 2461292.
Wang D, Villasante A, Lewis SA, Cowan NJ (1987). "The mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype". J. Cell Biol. 103 (5): 1903–10. doi:10.1083/jcb.103.5.1903. PMC 2114403. PMID 3782288.
Watts NR, Sackett DL, Ward RD, et al. (2000). "HIV-1 Rev Depolymerizes Microtubules to Form Stable Bilayered Rings". J. Cell Biol. 150 (2): 349–60. doi:10.1083/jcb.150.2.349. PMC 2180222. PMID 10908577.
Szalay J, Bruno P, Bhati R, et al. (2001). "Associations of PKC isoforms with the cytoskeleton of B16F10 melanoma cells". J. Histochem. Cytochem. 49 (1): 49–66. doi:10.1177/002215540104900106. PMID 11118478.
Tarazona R, López-Lluch G, Galiani MD, et al. (2001). "HLA-B2702 (77-83/83-77) peptide binds to beta-tubulin on human NK cells and blocks their cytotoxic capacity". J. Immunol. 165 (12): 6776–82. doi:10.4049/jimmunol.165.12.6776. PMID 11120798.
Walss-Bass C, Xu K, David S, et al. (2003). "Occurrence of nuclear beta(II)-tubulin in cultured cells". Cell Tissue Res. 308 (2): 215–23. doi:10.1007/s00441-002-0539-6. PMID 12037579. S2CID 25518226.
Krebs DL, Uren RT, Metcalf D, et al. (2002). "SOCS-6 Binds to Insulin Receptor Substrate 4, and Mice Lacking the SOCS-6 Gene Exhibit Mild Growth Retardation". Mol. Cell. Biol. 22 (13): 4567–78. doi:10.1128/MCB.22.13.4567-4578.2002. PMC 133908. PMID 12052866.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chen D, Wang M, Zhou S, Zhou Q (2004). "HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim". EMBO J. 21 (24): 6801–10. doi:10.1093/emboj/cdf683. PMC 139103. PMID 12486001.
Dozier JH, Hiser L, Davis JA, et al. (2003). "β class II tubulin predominates in normal and tumor breast tissues". Breast Cancer Res. 5 (5): R157–69. doi:10.1186/bcr631. PMC 314434. PMID 12927047.
Trinczek B, Brajenovic M, Ebneth A, Drewes G (2004). "MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes". J. Biol. Chem. 279 (7): 5915–23. doi:10.1074/jbc.M304528200. PMID 14594945.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Navarro-Lérida I, Martínez Moreno M, Roncal F, et al. (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8". Proteomics. 4 (2): 339–46. doi:10.1002/pmic.200300528. PMID 14760703. S2CID 8868600.
Campbell GR, Pasquier E, Watkins J, et al. (2005). "The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis". J. Biol. Chem. 279 (46): 48197–204. doi:10.1074/jbc.M406195200. PMID 15331610.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
de Mareuil J, Carre M, Barbier P, et al. (2006). "HIV-1 Tat protein enhances Microtubule polymerization". Retrovirology. 2: 5. doi:10.1186/1742-4690-2-5. PMC 549075. PMID 15691386.
Giacca M (2006). "HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?". Retrovirology. 2: 7. doi:10.1186/1742-4690-2-7. PMC 549042. PMID 15698476.
Ahmed M, Forsberg J, Bergsten P (2005). "Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry". J. Proteome Res. 4 (3): 931–40. doi:10.1021/pr050024a. PMID 15952740.

External links

TUBB4B human gene location in the UCSC Genome Browser.
TUBB4B human gene details in the UCSC Genome Browser.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000188229 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036752 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3999141-5] Lewis SA, Gilmartin ME, Hall JL, Cowan NJ (Jul 1985). "Three expressed sequences within the human beta-tubulin multigene family each define a distinct isotype". J Mol Biol. 182 (1): 11–20. doi:10.1016/0022-2836(85)90023-3. PMID 3999141.

[entrez-6] "Entrez Gene: TUBB2C tubulin, beta 2C".

Tubulin beta-4B chain

References

Further reading

External links