TUBGCP3

TUBGCP3
Identifiers
Aliases	TUBGCP3, 104p, GCP3, Grip104, SPBC98, Spc98, Spc98p, tubulin gamma complex associated protein 3, ALP6
External IDs	OMIM: 617818 MGI: 2183752 HomoloGene: 4609 GeneCards: TUBGCP3
Gene location (Human)
Chr.	Chromosome 13 (human)[1]
End	112,588,205 bp[1]
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)[2]
End	12,722,248 bp[2]
RNA expression pattern
	Top expressed in
	monocyte; ; bone marrow cells; ; ganglionic eminence; ; gastric mucosa; ; tibial nerve; ; right lobe of liver; ; skin of abdomen; ; appendix; ; canal of the cervix; ; left uterine tube;
	Top expressed in
	thymus; ; cerebellar cortex; ; superior frontal gyrus; ; dorsomedial hypothalamic nucleus; ; dermis; ; neural tube; ; medullary collecting duct; ; ganglionic eminence; ; yolk sac; ; ventromedial nucleus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	structural molecule activity; structural constituent of cytoskeleton; protein binding; microtubule minus-end binding; gamma-tubulin binding;
Cellular component	cytoplasm; cytosol; centrosome; spindle pole; equatorial microtubule organizing center; membrane; spindle; microtubule organizing center; gamma-tubulin small complex; polar microtubule; spindle pole body; centriole; cytoskeleton; microtubule; gamma-tubulin complex;
Biological process	centrosome duplication; microtubule nucleation by interphase microtubule organizing center; single fertilization; mitotic spindle assembly; cytoplasmic microtubule organization; microtubule cytoskeleton organization; microtubule nucleation; meiosis; mitotic cell cycle; spindle assembly;
	Sources:Amigo / QuickGO
Orthologs
	10426
	259279
	ENSG00000282003; ENSG00000126216
	ENSMUSG00000000759
	Q96CW5
	P58854
	NM_001286277; NM_001286278; NM_001286279; NM_006322
	NM_198031
	NP_001273206; NP_001273207; NP_001273208; NP_006313
	NP_932148
	Wikidata
View/Edit Human	View/Edit Mouse

Gamma-tubulin complex component 3 is a protein that in humans is encoded by the TUBGCP3 gene.[5][6][7] It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

References

ENSG00000126216 GRCh38: Ensembl release 89: ENSG00000282003, ENSG00000126216 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000000759 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Murphy SM, Urbani L, Stearns T (Jun 1998). "The mammalian gamma-tubulin complex contains homologues of the yeast spindle pole body components spc97p and spc98p". J Cell Biol. 141 (3): 663–74. doi:10.1083/jcb.141.3.663. PMC 2132743. PMID 9566967.
Tassin AM, Celati C, Moudjou M, Bornens M (Jun 1998). "Characterization of the human homologue of the yeast spc98p and its association with gamma-tubulin". J Cell Biol. 141 (3): 689–701. doi:10.1083/jcb.141.3.689. PMC 2132749. PMID 9566969.
"Entrez Gene: TUBGCP3 tubulin, gamma complex associated protein 3".

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Takahashi M, Yamagiwa A, Nishimura T, et al. (2003). "Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex". Mol. Biol. Cell. 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. PMC 124155. PMID 12221128.
Murphy SM, Preble AM, Patel UK, et al. (2002). "GCP5 and GCP6: two new members of the human gamma-tubulin complex". Mol. Biol. Cell. 12 (11): 3340–52. doi:10.1091/mbc.12.11.3340. PMC 60259. PMID 11694571.

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[refGRCh38Ensembl-1] ENSG00000126216 GRCh38: Ensembl release 89: ENSG00000282003, ENSG00000126216 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000759 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9566967-5] Murphy SM, Urbani L, Stearns T (Jun 1998). "The mammalian gamma-tubulin complex contains homologues of the yeast spindle pole body components spc97p and spc98p". J Cell Biol. 141 (3): 663–74. doi:10.1083/jcb.141.3.663. PMC 2132743. PMID 9566967.

[pmid9566969-6] Tassin AM, Celati C, Moudjou M, Bornens M (Jun 1998). "Characterization of the human homologue of the yeast spc98p and its association with gamma-tubulin". J Cell Biol. 141 (3): 689–701. doi:10.1083/jcb.141.3.689. PMC 2132749. PMID 9566969.

[entrez-7] "Entrez Gene: TUBGCP3 tubulin, gamma complex associated protein 3".

TUBGCP3

See also

References

Further reading