TUSC3

Tumor suppressor candidate 3 is a protein that in humans is encoded by the TUSC3 gene.[5][6][7]

TUSC3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTUSC3, D8S1992, M33, MRT22, MRT7, N33, OST3A, tumor suppressor candidate 3, MagT2, SLC58A2
External IDsOMIM: 601385 MGI: 1933134 HomoloGene: 6937 GeneCards: TUSC3
Orthologs
SpeciesHumanMouse
Entrez

7991

80286

Ensembl

ENSG00000104723

ENSMUSG00000118664

UniProt

Q13454

Q8BTV1

RefSeq (mRNA)

NM_006765
NM_178234
NM_001356429

NM_030254
NM_001357304
NM_001357305
NM_001357306

RefSeq (protein)

NP_006756
NP_839952
NP_001343358

NP_084530
NP_001344233
NP_001344234
NP_001344235

Location (UCSC)Chr 8: 15.42 – 15.77 MbChr 8: 39.47 – 39.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is a candidate tumor suppressor gene. It is located within a deleted region of a metastatic prostate cancer. The gene is expressed in most nonlymphoid human tissues including prostate, lung, liver, and colon. Expression was also detected in many epithelial tumor cell lines. Two transcript variants encoding distinct isoforms have been identified for this gene.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000104723 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000118664 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. MacGrogan D, Levy A, Bova GS, Isaacs WB, Bookstein R (Sep 1996). "Structure and methylation-associated silencing of a gene within a homozygously deleted region of human chromosome band 8p22". Genomics. 35 (1): 55–65. doi:10.1006/geno.1996.0322. PMID 8661104.
  6. Ishii H, Baffa R, Numata SI, Murakumo Y, Rattan S, Inoue H, Mori M, Fidanza V, Alder H, Croce CM (May 1999). "The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors". Proc Natl Acad Sci U S A. 96 (7): 3928–33. Bibcode:1999PNAS...96.3928I. doi:10.1073/pnas.96.7.3928. PMC 22397. PMID 10097140.
  7. "Entrez Gene: TUSC3 tumor suppressor candidate 3".

Further reading


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