TXNIP

Thioredoxin-interacting protein is a protein that in humans is encoded by the TXNIP gene.[5][6]

TXNIP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTXNIP, thioredoxin interacting protein, EST01027, HHCPA78, THIF, VDUP1, ARRDC6
External IDsOMIM: 606599 MGI: 1889549 HomoloGene: 38186 GeneCards: TXNIP
Orthologs
SpeciesHumanMouse
Entrez

10628

56338

Ensembl

ENSG00000265972

ENSMUSG00000038393

UniProt

Q9H3M7

Q8BG60

RefSeq (mRNA)

NM_006472
NM_001313972

NM_001009935
NM_023719

RefSeq (protein)

NP_001300901
NP_006463

NP_001009935
NP_076208

Location (UCSC)Chr 1: 145.99 – 146 MbChr 3: 96.47 – 96.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

TXNIP has been shown to interact with Thioredoxin[7] and ZBTB32.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000265972 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000038393 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chen KS, DeLuca HF (Sep 1994). "Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1219 (1): 26–32. doi:10.1016/0167-4781(94)90242-9. PMID 8086474.
  6. "Entrez Gene: TXNIP thioredoxin interacting protein".
  7. Nishiyama A, Matsui M, Iwata S, Hirota K, Masutani H, Nakamura H, Takagi Y, Sono H, Gon Y, Yodoi J (Jul 1999). "Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression". The Journal of Biological Chemistry. 274 (31): 21645–50. doi:10.1074/jbc.274.31.21645. PMID 10419473.
  8. Han SH, Jeon JH, Ju HR, Jung U, Kim KY, Yoo HS, Lee YH, Song KS, Hwang HM, Na YS, Yang Y, Lee KN, Choi I (Jun 2003). "VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression". Oncogene. 22 (26): 4035–46. doi:10.1038/sj.onc.1206610. PMID 12821938.

Further reading


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