Thiazovivin

Thiazovivin is a drug which acts as a potent and selective inhibitor of the enzyme Rho kinase. It is used alongside a cocktail of other growth factors and modulators in cell culture techniques for the generation of induced pluripotent stem cells, which can then be used for a wide variety of applications.[1][2][3][4]

Thiazovivin
Identifiers
  • N-benzyl-2-(pyrimidin-4-ylamino)-1,3-thiazole-4-carboxamide
CAS Number
PubChem CID
ChemSpider
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.236.307
Chemical and physical data
FormulaC15H13N5OS
Molar mass311.36 g·mol−1
3D model (JSmol)
  • C1=CC=C(C=C1)CNC(=O)C2=CSC(=N2)NC3=NC=NC=C3
  • InChI=1S/C15H13N5OS/c21-14(17-8-11-4-2-1-3-5-11)12-9-22-15(19-12)20-13-6-7-16-10-18-13/h1-7,9-10H,8H2,(H,17,21)(H,16,18,19,20)
  • Key:DOBKQCZBPPCLEG-UHFFFAOYSA-N

See also

References
  1. Lin T, Ambasudhan R, Yuan X, Li W, Hilcove S, Abujarour R, et al. (November 2009). "A chemical platform for improved induction of human iPSCs". Nature Methods. 6 (11): 805–8. doi:10.1038/nmeth.1393. PMC 3724527. PMID 19838168.
  2. Donai K, Inagaki A, So KH, Kuroda K, Sone H, Kobayashi M, et al. (March 2015). "Low-molecular-weight inhibitors of cell differentiation enable efficient growth of mouse iPS cells under feeder-free conditions". Cytotechnology. 67 (2): 191–7. doi:10.1007/s10616-013-9686-8. PMC 4329295. PMID 24682663.
  3. Mohseni R, Shoae-Hassani A, Verdi J (May 2015). "Reprogramming of endometrial adult stromal cells in the presence of a ROCK inhibitor, thiazovivin, could obtain more efficient iPSCs". Cell Biology International. 39 (5): 515–8. doi:10.1002/cbin.10411. PMID 25490878. S2CID 24813753.
  4. Cheng L, Lei Q, Yin C, Wang HY, Jin K, Xiang M (2017). "Generation of Urine Cell-Derived Non-integrative Human iPSCs and iNSCs: A Step-by-Step Optimized Protocol". Frontiers in Molecular Neuroscience. 10: 348. doi:10.3389/fnmol.2017.00348. PMC 5670152. PMID 29163026.
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