Thiolysis

Thiolysis is a reaction with a thiol (R-SH) that cleaves one compound into two.[1] Thiolysis involves the addition of coenzyme A to one of the products. This reaction is similar to hydrolysis, which involves water instead of a thiol.[2] This reaction is seen in β-oxidation of fatty acids.[3] The depolymerisation of condensed tannins with the use of benzyl mercaptan as nucleophile is also called thiolysis.[4]

Example of thiolysis (thiol: CoA-SH)

References
  1. Rao, Balaji; Simpson, Carolyne; Lin, Hui; Liang, Liyuan; Gu, Baohua (2014-11-02). "Determination of thiol functional groups on bacteria and natural organic matter in environmental systems". Talanta. 119: 240–247. doi:10.1016/j.talanta.2013.11.004. ISSN 1873-3573. PMID 24401410.
  2. Huang, Chun-Jen (2019-01-01), Mitsubayashi, Kohji; Niwa, Osamu; Ueno, Yuko (eds.), "5 - Advanced surface modification technologies for biosensors", Chemical, Gas, and Biosensors for Internet of Things and Related Applications, Elsevier, pp. 65–86, ISBN 978-0-12-815409-0, retrieved 2023-01-04
  3. Adeva-Andany, María M.; Carneiro-Freire, Natalia; Seco-Filgueira, Mónica; Fernández-Fernández, Carlos; Mouriño-Bayolo, David (2018-03-15). "Mitochondrial β-oxidation of saturated fatty acids in humans". Mitochondrion. 46: 73–90. doi:10.1016/j.mito.2018.02.009. ISSN 1872-8278. PMID 29551309. S2CID 4303820.
  4. Rubert-Nason, Kennedy F.; Lindroth, Richard L. (2018-12-11). "Analysis of condensed tannins in Populus spp. using reversed phase UPLC-PDA-(-)esi-MS following thiolytic depolymerisation". Phytochemical Analysis. 30 (3): 257–267. doi:10.1002/pca.2810. ISSN 1099-1565. PMID 30548354. S2CID 56486911.
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