3-oxoacid CoA-transferase

In enzymology, a 3-oxoacid CoA-transferase (EC 2.8.3.5) is an enzyme that catalyzes the chemical reaction

succinyl-CoA + a 3-oxo acid succinate + a 3-oxoacyl-CoA
3-oxoacid CoA-transferase (SCOT)
Pig succinyl-CoA 3-oxoacid transferase PDB: 3K6M​
Identifiers
EC no.2.8.3.5
CAS no.9027-43-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Thus, the two substrates of this enzyme are succinyl-CoA and 3-oxo acid, whereas its two products are succinate and 3-oxoacyl-CoA.

This enzyme belongs to the family of transferases, specifically the CoA-transferases. The systematic name of this enzyme class is succinyl-CoA:3-oxo-acid CoA-transferase. Other names in common use include succinyl-CoA-3-ketoacid-CoA transferase, 3-oxoacid coenzyme A-transferase, 3-ketoacid CoA-transferase, 3-ketoacid coenzyme A transferase, 3-oxo-CoA transferase, 3-oxoacid CoA dehydrogenase, acetoacetate succinyl-CoA transferase, acetoacetyl coenzyme A-succinic thiophorase, succinyl coenzyme A-acetoacetyl coenzyme A-transferase, and succinyl-CoA transferase. This enzyme participates in 3 metabolic pathways: synthesis and degradation of ketone bodies,[1] valine, leucine and isoleucine degradation, and butanoate metabolism.

This protein may use the morpheein model of allosteric regulation.[2]

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1M3E, 1O9L, 1OOY, 1OOZ, 1OPE, 2NRB, and 2NRC.

References
  1. Blanco, Antonio; Blanco, Gustavo (2017), "Chapter 15 - Lipid Metabolism", Medical Biochemistry, Academic Press, pp. 325–365, doi:10.1016/b978-0-12-803550-4.00015-x, ISBN 978-0-12-803550-4, retrieved 2023-06-08
  2. T. Selwood & E. K. Jaffe (2011). "Dynamic dissociating homo-oligomers and the control of protein function". Arch. Biochem. Biophys. 519 (2): 131–43. doi:10.1016/j.abb.2011.11.020. PMC 3298769. PMID 22182754.


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