Thymidine kinase 1

Thymidine kinase 1, soluble (gene name TK1), is a human thymidine kinase.[5]

TK1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTK1, TK2, Thymidine kinase 1
External IDsOMIM: 188300 MGI: 98763 HomoloGene: 37749 GeneCards: TK1
Orthologs
SpeciesHumanMouse
Entrez

7083

21877

Ensembl

ENSG00000167900

ENSMUSG00000025574

UniProt

P04183

P04184

RefSeq (mRNA)

NM_003258
NM_001346663
NM_001363848

NM_001271729
NM_009387

RefSeq (protein)

NP_001333592
NP_003249
NP_001350777

NP_001258658
NP_033413

Location (UCSC)Chr 17: 78.17 – 78.19 MbChr 11: 117.71 – 117.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Two forms of this protein have been identified in animal cells, one in cytosol and one in mitochondria. Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells.

Interactions

Thymidine kinase 1 has been shown to interact with P21.[6]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.[§ 1]

[[File:
FluoropyrimidineActivity_WP1601
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FluoropyrimidineActivity_WP1601
|alt=Fluorouracil (5-FU) Activity edit]]
Fluorouracil (5-FU) Activity edit
  1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

Thymidine Kinase 1 in Cancer

Elevations in serum TK-1 have been found to correlate with the return of breast and other forms of cancer[7] TK-1 can be used to detect cancer earlier, determine what stage it is in, and detect recurrence. Thymidine Kinase 1 can be measured based on its enzyme activity[8] or using immunoassay.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000167900 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000025574 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Thymidine kinase 1, soluble".
  6. Huang DY, Chang ZF (June 2001). "Interaction of human thymidine kinase 1 with p21(Waf1)". Biochem. J. 356 (Pt 3): 829–34. doi:10.1042/0264-6021:3560829. PMC 1221910. PMID 11389691.
  7. Alegre MM, Robison RA, O'Neill KL (2012). "Thymidine kinase 1 up-regulation is an early event in breast tumor formation". Journal of Oncology. 2012: 575647. doi:10.1155/2012/575647. PMC 3388419. PMID 22778736.
  8. Munch-Petersen B (2005). "Differences in the kinetic properties of thymidine kinase isoenzymes in unstimulated and phytohemagglutinin-stimulated human lymphocytes". Mol. Cell. Biochem. 64 (2): 1013–19. doi:10.1007/BF00224774. PMID 6504022. S2CID 11326439.
  9. He Q, Zhang P, Zou L, et al. (2005). "Concentration of thymidine kinase 1 in serum (S-TK1) is a more sensitive proliferation marker in human solid tumors than its activity". Oncol. Rep. 14 (4): 1013–19. PMID 16142366.

Further reading


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