Thyroid-hormone transaminase

In enzymology, a thyroid-hormone transaminase (EC 2.6.1.26) is an enzyme that catalyzes the chemical reaction

L-3,5,3'-triiodothyronine + 2-oxoglutarate 3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate + L-glutamate
Thyroid-hormone transaminase
Identifiers
EC no.2.6.1.26
CAS no.51004-29-6
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Thus, the two substrates of this enzyme are L-3,5,3'-triiodothyronine and 2-oxoglutarate, whereas its two products are [[3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-2-oxopropanoate]] and L-glutamate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-3,5,3'-triiodothyronine:2-oxoglutarate aminotransferase. Other names in common use include 3,5-dinitrotyrosine transaminase, and thyroid hormone aminotransferase. It employs one cofactor, pyridoxal phosphate.

References

    • Soffer RL, Hechtman P, Savage M (1973). "L-Triiodothyronine aminotransferase". J. Biol. Chem. 248 (4): 1224–30. PMID 4686924.


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