Tm2 domain containing 1

TM2 domain containing 1 is a protein that in humans is encoded by the TM2D1 gene. [5]

TM2D1
Identifiers
AliasesTM2D1, BBP, TM2 domain containing 1
External IDsOMIM: 610080 MGI: 2137022 HomoloGene: 12928 GeneCards: TM2D1
Orthologs
SpeciesHumanMouse
Entrez

83941

94043

Ensembl

ENSG00000162604

ENSMUSG00000028563

UniProt

Q9BX74

Q99MB3

RefSeq (mRNA)

NM_032027

NM_053157

RefSeq (protein)

NP_114416

NP_444387

Location (UCSC)Chr 1: 61.68 – 61.73 MbChr 4: 98.24 – 98.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a beta-amyloid peptide-binding protein. It contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily and known to be important in heterotrimeric G protein activation. Beta-amyloid peptide has been established to be a causative factor in neuron death and the consequent diminution of cognitive abilities observed in Alzheimer's disease. This protein may be a target of neurotoxic beta-amyloid peptide, and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death. Several transcript variants have been found for this gene.

References
  1. GRCh38: Ensembl release 89: ENSG00000162604 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028563 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: TM2 domain containing 1". Retrieved 2017-05-19.

Further reading
  • Kirfel G, Borm B, Rigort A, Herzog V (2002). "The secretory beta-amyloid precursor protein is a motogen for human epidermal keratinocytes". Eur. J. Cell Biol. 81 (12): 664–76. doi:10.1078/0171-9335-00284. PMID 12553667.
  • Lee Y, Chang DJ, Lee YS, Chang KA, Kim H, Yoon JS, Lee S, Suh YH, Kaang BK (2003). "Beta-amyloid peptide binding protein does not couple to G protein in a heterologous Xenopus expression system". J. Neurosci. Res. 73 (2): 255–9. doi:10.1002/jnr.10652. PMID 12836168. S2CID 32419466.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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