Trans,polycis-polyprenyl diphosphate synthase ((2Z,6E)-farnesyl diphosphate specific)

Trans,polycis-polyprenyl diphosphate synthase ((2Z,6E)-farnesyl diphosphate specific) (EC 2.5.1.88) is an enzyme with systematic name (2Z,6E)-farnesyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 9--11 isopentenyl units).[1] This enzyme catalyses the following chemical reaction

(2Z,6E)-farnesyl diphosphate + n isopentenyl diphosphate n diphosphate + trans,polycis-polyprenyl diphosphate (n = 9 - 11)
Trans,polycis-polyprenyl diphosphate synthase ((2Z,6E)-farnesyl diphosphate specific)
Identifiers
EC no.2.5.1.88
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

This enzyme has the highest activity with (2Z,6E)-farnesyl diphosphate as allylic substrate.

References

  1. Ambo T, Noike M, Kurokawa H, Koyama T (June 2009). "Cloning and functional analysis of cis-prenyltransferase from Thermobifida fusca". Journal of Bioscience and Bioengineering. 107 (6): 620–2. doi:10.1016/j.jbiosc.2009.02.006. PMID 19447338.
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