Translin

Translin is a DNA-binding protein that in humans is encoded by the TSN gene.[5][6][7] Together with translin-associated factor X, translin forms the component 3 of promoter of RISC (C3PO) complex which facilitates endonucleolytic cleavage of the passenger strand during microRNA loading into the RNA-induced silencing complex (RISC).[8][9][10]

TSN
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTSN, BCLF-1, C3PO, RCHF1, REHF-1, TBRBP, TRSLN, translin
External IDsOMIM: 600575 MGI: 109263 HomoloGene: 3397 GeneCards: TSN
Orthologs
SpeciesHumanMouse
Entrez

7247

22099

Ensembl

ENSG00000211460

ENSMUSG00000026374

UniProt

Q15631

Q62348

RefSeq (mRNA)

NM_001261401
NM_004622

NM_011650

RefSeq (protein)

NP_001248330
NP_004613

NP_035780

Location (UCSC)Chr 2: 121.74 – 121.77 MbChr 1: 118.22 – 118.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms.[7]

Interactions

Translin has been shown to interact with PPP1R15A.[11]

References

  1. GRCh38: Ensembl release 89: ENSG00000211460 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026374 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kasai M, Aoki K, Matsuo Y, Minowada J, Maziarz RT, Strominger JL (July 1994). "Recombination hotspot associated factors specifically recognize novel target sequences at the site of interchromosomal rearrangements in T-ALL patients with t(8;14)(q24;q11) and t(1;14)(p32;q11)". International Immunology. 6 (7): 1017–25. doi:10.1093/intimm/6.7.1017. PMID 7947454.
  6. Aoki K, Inazawa J, Takahashi T, Nakahara K, Kasai M (July 1997). "Genomic structure and chromosomal localization of the gene encoding translin, a recombination hotspot binding protein". Genomics. 43 (2): 237–41. doi:10.1006/geno.1997.4796. PMID 9244443.
  7. "Entrez Gene: TSN translin".
  8. Liu Y, Ye X, Jiang F, Liang C, Chen D, Peng J, Kinch LN, Grishin NV, Liu Q (August 2009). "C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation". Science. 325 (5941): 750–3. Bibcode:2009Sci...325..750L. doi:10.1126/science.1176325. PMC 2855623. PMID 19661431.
  9. Ye X, Huang N, Liu Y, Paroo Z, Huerta C, Li P, Chen S, Liu Q, Zhang H (June 2011). "Structure of C3PO and mechanism of human RISC activation". Nature Structural & Molecular Biology. 18 (6): 650–7. doi:10.1038/nsmb.2032. PMC 3109212. PMID 21552258.
  10. Ha M, Kim VN (August 2014). "Regulation of microRNA biogenesis". Nature Reviews Molecular Cell Biology. 15 (8): 509–24. doi:10.1038/nrm3838. PMID 25027649. S2CID 205495632.
  11. Hasegawa T, Isobe K (August 1999). "Evidence for the interaction between Translin and GADD34 in mammalian cells". Biochimica et Biophysica Acta (BBA) - General Subjects. 1428 (2–3): 161–8. doi:10.1016/s0304-4165(99)00060-4. PMID 10434033.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: Q15631 (Human Translin) at the PDBe-KB.
  • Overview of all the structural information available in the PDB for UniProt: Q62348 (Mouse Translin) at the PDBe-KB.


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