Trimethylamine dehydrogenase
In enzymology, a trimethylamine dehydrogenase (EC 1.5.8.2) is an enzyme that catalyzes the chemical reaction
- trimethylamine + H2O + electron-transferring flavoprotein dimethylamine + formaldehyde + reduced electron-transferring flavoprotein
| trimethylamine dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.5.8.2 | ||||||||
| CAS no. | 39307-09-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The 3 substrates of this enzyme are trimethylamine, H2O, and electron-transferring flavoprotein, whereas its 3 products are dimethylamine, formaldehyde, and reduced electron-transferring flavoprotein.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with a flavin as acceptor. The systematic name of this enzyme class is trimethylamine:electron-transferring flavoprotein oxidoreductase (demethylating). This enzyme participates in methane metabolism.
References
- Colby J; Zatman LJ (1971). "The purification and properties of a bacterial trimethylamine dehydrogenase". Biochem. J. 121 (1): 9P–10P. PMC 1176516. PMID 5116569.
- Steenkamp DJ, Singer TP (1978). "Participation of the iron-sulphur cluster and of the covalently bound coenzyme of trimethylamine dehydrogenase in catalysis". Biochem. J. 169 (2): 361–9. PMC 1184175. PMID 204297.
- Huang L, Rohlfs RJ, Hille R (1995). "The reaction of trimethylamine dehydrogenase with electron transferring flavoprotein". J. Biol. Chem. 270 (41): 23958–65. doi:10.1074/jbc.270.41.23958. PMID 7592591.
- Jones M; Talfournier, F; Bobrov, A; Grossmann, JG; Vekshin, N; Sutcliffe, MJ; Scrutton, NS (2002). "Electron transfer and conformational change in complexes of trimethylamine dehydrogenase and electron transferring flavoprotein". J. Biol. Chem. 277 (10): 8457–65. doi:10.1074/jbc.M111105200. PMID 11756429.
- Scrutton NS, Sutcliffe MJ (2000). "Trimethylamine dehydrogenase and electron transferring flavoprotein". Subcell. Biochem. 35: 145–81. doi:10.1007/0-306-46828-X_5. PMID 11192721.
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