Trimethylsulfonium—tetrahydrofolate N-methyltransferase

In enzymology, a trimethylsulfonium-tetrahydrofolate N-methyltransferase (EC 2.1.1.19) is an enzyme that catalyzes the chemical reaction

trimethylsulfonium + tetrahydrofolate dimethylsulfide + 5-methyltetrahydrofolate
trimethylsulfonium-tetrahydrofolate N-methyltransferase
Identifiers
EC no.2.1.1.19
CAS no.37256-92-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

Thus, the two substrates of this enzyme are trimethylsulfonium and tetrahydrofolate, whereas its two products are dimethyl sulfide and 5-methyltetrahydrofolate.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is trimethylsulfonium:tetrahydrofolate N-methyltransferase. This enzyme is also called trimethylsulfonium-tetrahydrofolate methyltransferase. This enzyme participates in one carbon pool by folate.

References

    • Wagner C, Lusty SM, Kung HF, Rogers NL (1967). "Preparation and properties of trimethylsulfonium-tetrahydrofolate methyltransferase". J. Biol. Chem. 242 (6): 1287–93. PMID 6023571.


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