Trimethylsulfonium—tetrahydrofolate N-methyltransferase
In enzymology, a trimethylsulfonium-tetrahydrofolate N-methyltransferase (EC 2.1.1.19) is an enzyme that catalyzes the chemical reaction
- trimethylsulfonium + tetrahydrofolate dimethylsulfide + 5-methyltetrahydrofolate
| trimethylsulfonium-tetrahydrofolate N-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.19 | ||||||||
| CAS no. | 37256-92-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are trimethylsulfonium and tetrahydrofolate, whereas its two products are dimethyl sulfide and 5-methyltetrahydrofolate.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is trimethylsulfonium:tetrahydrofolate N-methyltransferase. This enzyme is also called trimethylsulfonium-tetrahydrofolate methyltransferase. This enzyme participates in one carbon pool by folate.
References
- Wagner C, Lusty SM, Kung HF, Rogers NL (1967). "Preparation and properties of trimethylsulfonium-tetrahydrofolate methyltransferase". J. Biol. Chem. 242 (6): 1287–93. PMID 6023571.
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