Lamivudine/nevirapine/stavudine

Lamivudine/nevirapine/stavudine (3TC/NVP/d4T) is a fixed-dose combination antiretroviral medication used to treat HIV/AIDS.[1] It contains lamivudine, nevirapine, and stavudine.[1] It is either used by itself or along with other antiretrovirals.[1] It is taken by mouth twice a day.[1]

Lamivudine/nevirapine/stavudine
Combination of
Lamivudinenucleoside reverse transcriptase inhibitor
Nevirapinenon-nucleoside reverse transcriptase inhibitor
Stavudinenucleoside reverse transcriptase inhibitor
Clinical data
Trade namesTriomune, others
ATC code
Identifiers
CAS Number
ChemSpider
  • none

It is on the World Health Organization's List of Essential Medicines.[2] As of 2015, it is not commercially available in the United States.[3]

Medical uses

It is a common first line treatment in the developing world.[4]

Adverse effects and safety

The medication is generally well tolerated.[5] Side effects are those of the underlying medications.[1] This may include rash, numbness, pancreatitis, and high blood lactate levels.[5] Use is not recommended in those with significant liver problems.[5] It is unclear if use in pregnancy is safe for the baby and recommendations include starting in the second trimester if possible.[5]

References
  1. World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. p. 160. hdl:10665/44053. ISBN 9789241547659.
  2. World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  3. Kasper DL, Fauci AS, Hauser S, Longo D, Jameson JL, Loscalzo J (2015). Harrison's Principles of Internal Medicine 19/E (Vol.1 & Vol.2). McGraw Hill Professional. p. 1277. ISBN 9780071802161. Archived from the original on 2016-12-20.
  4. Siegfried NL, Van Deventer PJ, Mahomed FA, Rutherford GW (April 2006). "Stavudine, lamivudine and nevirapine combination therapy for treatment of HIV infection and AIDS in adults". The Cochrane Database of Systematic Reviews. 2006 (2): CD004535. doi:10.1002/14651858.CD004535.pub2. PMC 8407055. PMID 16625606.
  5. "Nevirapine/stavudine/lamivudine" (PDF). aidsmap. Archived from the original (PDF) on 20 December 2016. Retrieved 18 December 2016.
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