Tryptophan N-monooxygenase
Tryptophan N-monooxygenase (EC 1.14.13.125, tryptophan N-hydroxylase, CYP79B1, CYP79B2, CYP79B3) is an enzyme with systematic name L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating).[1][2][3][4] This enzyme catalyses the following chemical reaction
- L-tryptophan + 2 O2 + 2 NADPH + 2 H+ (E)-indol-3-ylacetaldoxime + 2 NADP+ + CO2 + 3 H2O (overall reaction)
- (1a) L-tryptophan + O2 + NADPH + H+ N-hydroxy-L-tryptophan + NADP+ + H2O
- (1b) N-hydroxy-L-tryptophan + O2 + NADPH + H+ N,N-dihydroxy-L-tryptophan + NADP+ + H2O
- (1c) N,N-dihydroxy-L-tryptophan (E)-indol-3-ylacetaldoxime + CO2 + H2O
| Tryptophan N-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.13.125 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Tryptophan N-monooxygenase is a heme-thiolate protein (P-450).
References
- Mikkelsen MD, Hansen CH, Wittstock U, Halkier BA (October 2000). "Cytochrome P450 CYP79B2 from Arabidopsis catalyzes the conversion of tryptophan to indole-3-acetaldoxime, a precursor of indole glucosinolates and indole-3-acetic acid". The Journal of Biological Chemistry. 275 (43): 33712–7. doi:10.1074/jbc.M001667200. PMID 10922360.
- Hull AK, Vij R, Celenza JL (February 2000). "Arabidopsis cytochrome P450s that catalyze the first step of tryptophan-dependent indole-3-acetic acid biosynthesis". Proceedings of the National Academy of Sciences of the United States of America. 97 (5): 2379–84. Bibcode:2000PNAS...97.2379H. doi:10.1073/pnas.040569997. PMC 15809. PMID 10681464.
- Zhao Y, Hull AK, Gupta NR, Goss KA, Alonso J, Ecker JR, Normanly J, Chory J, Celenza JL (December 2002). "Trp-dependent auxin biosynthesis in Arabidopsis: involvement of cytochrome P450s CYP79B2 and CYP79B3". Genes & Development. 16 (23): 3100–12. doi:10.1101/gad.1035402. PMC 187496. PMID 12464638.
- Naur P, Hansen CH, Bak S, Hansen BG, Jensen NB, Nielsen HL, Halkier BA (January 2003). "CYP79B1 from Sinapis alba converts tryptophan to indole-3-acetaldoxime". Archives of Biochemistry and Biophysics. 409 (1): 235–41. doi:10.1016/s0003-9861(02)00567-2. PMID 12464264.
External links
- Tryptophan+N-monooxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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