Telmisartan/amlodipine

Telmisartan/amlodipine, sold under the brand name Twynsta among others, is a fixed-dose combination medication used to treat high blood pressure.[1] It is a combination of telmisartan, an angiotensin II receptor antagonist, and amlodipine, as the besilate, a calcium channel blocker.[1] It is taken by mouth.[1]

Common side effects include dizziness, swelling, and back pain.[1] Severe side effects may include low blood pressure, kidney problems, electrolyte problems, and a heart attack.[1] Use during pregnancy may harm the baby.[1] Telmisartan works by blocking the effects of angiotensin II while amlodipine works by decreasing calcium ion entry into smooth muscle and heart muscle.[1]

The combination was approved for medical use in the United States in 2009.[1] The combination is on the World Health Organization's List of Essential Medicines.[3][4] It is available as a generic medication.[5]