Tympanic membrane retraction

Tympanic membrane retraction describes a condition in which a part of the eardrum lies deeper within the ear than its normal position.

Tympanic membrane retraction
Endoscopic image of retracted left tympanic membrane

The eardrum comprises two parts: the pars tensa, which is the main part of the eardrum, and the pars flaccida, which is a smaller part of the eardrum located above the pars tensa. Either or both of these parts may become retracted. The retracted segment of eardrum is often known as a retraction pocket. The terms atelectasis or sometimes adhesive otitis media can be used to describe retraction of a large area of the pars tensa.

Tympanic membrane retraction is fairly common and has been observed in one quarter of a population of British school children.[1] Retraction of both eardrums is less common than having a retraction in just one ear. It is more common in children with cleft palate.[2] Tympanic membrane retraction also occurs in adults.[3][4]

Attempts have been made to categorise the extent of tympanic membrane retraction[3][4][5] though the validity of these classifications is limited.[2]

Presentation

The majority of tympanic membrane retractions do not cause any symptoms. Some cause hearing loss by restricting sound-induced vibrations of the eardrum. Permanent conductive hearing loss can be caused by erosion of the ossicles (hearing bones). Discharge from the ear often indicates that the retraction pocket has developed into a cholesteatoma.

Pathogenesis

Three factors must occur for the tympanic membrane to become retracted:

Negative middle ear pressure

When gas pressure within the middle ear is less than atmospheric pressure, the eardrum can become sucked into the middle ear space. This may be caused by disrupted gas exchange in the middle ear mucosa, inadequate opening of the Eustachian tube or a combination of these factors. People with a patulous Eustachian tube may also cause negative middle ear pressure by repeatedly sniffing to try to keep their Eustachian tube closed.[6]

Weakness of the tympanic membrane

The middle layer of the pars tensa is strengthened by fibers of collagen protein. This layer may be weaker in the postero-superior quadrant (top rear quarter) or after the eardrum heals after perforation or tympanostomy tubes (grommets) so predispose to retraction in these areas. The pars flaccida is prone to retraction as it does not contain the same stiffening layer of collagen.

Increase in surface area of the tympanic membrane

All over the body, new skin cells are continually produced to replace old skin cells which dry out and slough off. Growth of new cells on the surface of the eardrum is unusual in that the new cells migrate over the surface and move out along the ear canal. Even if migration along the ear canal is blocked, new cells continue to grow so the surface of the eardrum becomes larger. This process of proliferation and migration can result in enlargement of a retraction pocket so that the eardrum expands and grows deeper into the ear.

Natural history

The majority of tympanic membrane retractions remain stable for long periods of time, or may even resolve spontaneously so that the eardrum becomes normal again.[7] Not all retractions are able to resolve even if middle ear pressure normalizes, as the retracted segment may become adherent to other structures within the middle ear. Some retractions continue to progress and grow more deeply into the ear. This can result in erosion of bone and cholesteatoma formation. Asymptomatic deep pars tensa retractions tend to remain stable in adults. However, behaviour of symptomatic pars tensa retractions significantly differ between children and adults. There is a likelihood that such ears in children will recover spontaneously. There is no simple clinical means of identifying which ears will deteriorate to accumulate keratin debris in the pars tensa retraction, a phenomenon that is not influenced by age. In children, the pars tensa retraction may remain unchanged while the pars flaccida deteriorates to form cholesteatoma.[8]

Bone erosion

As the middle ear is only a narrow space, the eardrum only has to retract a short distance before it touches boney structures within the middle ear such as the ossicles. It may become adherent to these bones and in some cases, this contact leads to erosion of the bone. As well as ossicular erosion, the bone of the ear canal (e.g. the scutum) and even bone over the cochlea (the promontory) can become eroded.

Keratin entrapment

As skin cells die they form a barrier of dry protein called keratin. This layer of keratin is normally pushed out of the ear by migration of skin cells along the ear canal and is turned into wax. Clearance of keratin can be disrupted by tympanic membrane retraction so that keratin accumulates within the retraction pocket. When keratin becomes trapped deep inside the ear and cannot be cleaned out, it is known as cholesteatoma. Growth of bacteria in the trapped keratin causes smelly discharge from the ear and can spread to cause serious infection.

Treatment

Various strategies may be used to manage tympanic membrane retraction, with the aims of preventing or relieving hearing loss and cholesteatoma formation.

Observation

As retraction pockets may remain stable or resolve spontaneously, it may be appropriate to observe them for a period of time before considering any active treatment.[9]

Increase middle ear pressure

The Valsalva maneuver increases middle ear pressure and can push a retracted eardrum out of the middle ear if it is not adherent to middle ear structures. Hearing may improve as a result, however it can be a painful maneuver. The benefits are typically only temporary. Middle ear pressure can also be increased by Politzerization and with commercially available devices (e.g. Otovent and Ear Popper).

Ventilation tubes

A ventilation tube, also known as a tympanostomy tube or a grommet, may be placed through the eardrum to equalize middle ear pressure. Although this intervention may be effective, research has not yet shown whether it provides better results than simple observation.[10] Further weakness or perforation of the eardrum may occur.

Nasal treatments

These are intended to improve Eustachian tube function. Adenoidectomy can improve middle ear function[11] and nasal steroid sprays can reduce adenoid size[12] but it is not known whether these treatments alter tympanic membrane retraction.

Eustachian tube surgery

Enlargement of the Eustachian tube opening in the nose with laser or balloon dilatation is being evaluated as a potential treatment for tympanic membrane retraction.[13][14] There are two methods for this technique: Dennis Poe popularized the transnasal introduction of the balloon catheter to dilate the distal (nose end of the Eustachian tube).[14] Muaaz Tarabichi pioneered the dilatation of the proximal (ear side of the eustachian tube) through transtympanic (trans-ear) introduction of the balloon catheter.[15][16]

Retraction pocket surgery

Excision of the retracted segment of an eardrum, with or without placement of a tympanostomy tube has been advocated. Healing of the area can result in a more normal eardrum.[17] Laser therapy has been used to shrink and stiffen retraction pockets.[18]

Tympanoplasty

Tympanoplasty is the surgical technique of removal of the retracted area from the middle ear and reconstruction of the tympanic membrane. Some surgeons use cartilage (taken from the outer ear) to stiffen the eardrum with the aim of preventing further retraction.[9] Surgical removal is required once a cholesteatoma has formed.

References
  1. Maw, AR; Hall AJ; Pothier DD; Gregory SP; Steer CD. (2011). "The prevalence of tympanic membrane and related middle ear pathology in children: a large longitudinal cohort study followed from birth to age ten". Otology & Neurotology. 32 (8): 1256–61. doi:10.1097/mao.0b013e31822f10cf. PMID 21897314. S2CID 13913918.
  2. James AL, Papsin BC, Trimble K, Ramsden J, Sanjeevan N, Bailie N, Chadha NK (May 2012). "Tympanic membrane retraction: An endoscopic evaluation of staging systems". Laryngoscope. 122 (5): 1115–20. doi:10.1002/lary.23203. PMID 22374833. S2CID 6122719.
  3. Sadé, J; Berco E (1976). "Atelectasis and secretory otitis media". Ann Otol Rhinol Laryngol. 85 (2 Suppl 25 Pt 2): 66–72. doi:10.1177/00034894760850S214. PMID 1267370. S2CID 42460109.
  4. Tos, M; Poulsen G (1980). "Attic retractions following secretory otitis". Acta Otolaryngol. 89 (5–6): 479–86. doi:10.3109/00016488009127165. PMID 7192477.
  5. Borgstein, J; Gerritsma TV; Wieringa MH; Bruce IA (2007). "The Erasmus atelectasis classification: proposal of a new classification for atelectasis of the middle ear in children". Laryngoscope. 117 (7): 1255–9. doi:10.1097/mlg.0b013e31805d0160. PMID 17603325. S2CID 21170363.
  6. Ikeda, R; Oshima T; Oshima H; Miyazaki M; Kikuchi T; Kawase T; Kobayashi T (2011). "Management of patulous Eustachian tube with habitual sniffing". Otology & Neurotology. 32 (5): 790–3. doi:10.1097/mao.0b013e3182184e23. PMID 21659936. S2CID 25034104.
  7. MRC Multi-Centre Otitis Media Study Group (May 2001). "Pars tensa and pars flaccida retractions in persistent otitis media with effusion". Otol. Neurotol. 22 (3): 291–8. doi:10.1097/00129492-200105000-00004. PMID 11347629. S2CID 11338999.
  8. John Cutajar, Maryam Nowghani, Bharti Tulsidas-Mahtani, and John Hamilton (April 2018). "The Natural History of Asymptomatic Deep Pars Tensa Retraction". Int. Adv. Otol. 14 (1): 10–14. doi:10.5152/iao.2018.5234. PMC 6354506. PMID 29764774.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  9. Bluestone, Charles (2005). Eustachian Tube. Hamilton, ON: B C Decker Inc. pp. 189–192. ISBN 978-1-55009-066-6.
  10. Nankivell, PC; Pothier DD (7 Jul 2010). "Surgery for tympanic membrane retraction pockets". Cochrane Database Syst Rev. 7 (7): CD007943. doi:10.1002/14651858.CD007943.pub2. PMID 20614467.
  11. van den Aardweg, MT; Schilder AG; Herkert E; Boonacker CW; Rovers MM (20 January 2010). "Adenoidectomy for otitis media in children". Cochrane Database Syst Rev. CD007810 (1): CD007810. doi:10.1002/14651858.CD007810.pub2. PMID 20091650.
  12. Zhang, L; Mendoza-Sassi RA; César JA; Chadha NK (16 July 2008). "Intranasal corticosteroids for nasal airway obstruction in children with moderate to severe adenoidal hypertrophy". Cochrane Database Syst Rev. 3 (3): CD006286. doi:10.1002/14651858.CD006286.pub2. PMC 8923350. PMID 18646145.
  13. Poe, DS; Silvola J; Pyykkö I (2011). "Balloon dilation of the cartilaginous eustachian tube". Otolaryngol Head Neck Surg. 144 (4): 563–9. doi:10.1177/0194599811399866. PMID 21493236. S2CID 10717771.
  14. Poe, Dennis; Anand, Vijay; Dean, Marc; Roberts, William H.; Stolovitzky, Jose Pablo; Hoffmann, Karen; Nachlas, Nathan E.; Light, Joshua P.; Widick, Mark H.; Sugrue, John P.; Elliott, C. Layton (May 2018). "Balloon dilation of the eustachian tube for dilatory dysfunction: A randomized controlled trial: Balloon Dilation of the Eustachian Tube". The Laryngoscope. 128 (5): 1200–1206. doi:10.1002/lary.26827. PMID 28940574. S2CID 4968887.
  15. Tarabichi, Muaaz; Najmi, Murtaza (2015-07-03). "Transtympanic dilatation of the eustachian tube during chronic ear surgery". Acta Oto-Laryngologica. 135 (7): 640–644. doi:10.3109/00016489.2015.1009640. ISSN 0001-6489. PMID 25762371. S2CID 39239009.
  16. Kapadia, Mustafa; Tarabichi, Muaaz (October 2018). "Feasibility and Safety of Transtympanic Balloon Dilatation of Eustachian Tube". Otology & Neurotology. 39 (9): e825–e830. doi:10.1097/MAO.0000000000001950. ISSN 1531-7129. PMID 30124616. S2CID 52041093.
  17. Blaney, SP; Tierney P; Bowdler DA (1999). "The surgical management of the pars tensa retraction pocket in the child--results following simple excision and ventilation tube insertion". Int J Pediatr Otorhinolaryngol. 50 (2): 133–7. doi:10.1016/s0165-5876(99)00227-x. PMID 10576614.
  18. Brawner, JT; Saunders JE; Berryhill WE. (2008). "Laser myringoplasty for tympanic membrane atelectasis". Otolaryngol Head Neck Surg. 139 (1): 47–50. doi:10.1016/j.otohns.2008.01.018. PMID 18585560. S2CID 2457206.
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