UBR2

E3 ubiquitin-protein ligase UBR2 is an enzyme that in humans is encoded by the UBR2 gene.[5]

UBR2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesUBR2, C6orf133, bA49A4.1, dJ242G1.1, dJ392M17.3, ubiquitin protein ligase E3 component n-recognin 2
External IDsOMIM: 609134 MGI: 1861099 HomoloGene: 26151 GeneCards: UBR2
Orthologs
SpeciesHumanMouse
Entrez

23304

224826

Ensembl

ENSG00000024048

ENSMUSG00000023977

UniProt

Q8IWV8

Q6WKZ8

RefSeq (mRNA)

NM_001184801
NM_015255
NM_001363705

NM_001177374
NM_146078

RefSeq (protein)

NP_001171730
NP_056070
NP_001350634

NP_001170845
NP_666190

Location (UCSC)Chr 6: 42.56 – 42.69 MbChr 17: 47.24 – 47.32 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Proteolysis by the ubiquitin-proteasome system controls the concentration of many regulatory proteins. The selectivity of ubiquitylation is determined by ubiquitin E3 ligases, which recognize the substrate's destabilization signal, or degron. The E3 ligase UBR2 participates in the N-end rule pathway, which targets proteins bearing an N-terminal degron, or N-degron (Kwon et al., 2003).[supplied by OMIM][5]

References

  1. GRCh38: Ensembl release 89: ENSG00000024048 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000023977 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: UBR2 ubiquitin protein ligase E3 component n-recognin 2".

Further reading

  • Overview of all the structural information available in the PDB for UniProt: Q8IWV8 (E3 ubiquitin-protein ligase UBR2) at the PDBe-KB.
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