UDP-2,3-diacetamido-2,3-dideoxyglucuronic acid 2-epimerase

UDP-2,3-diacetamido-2,3-dideoxyglucuronic acid 2-epimerase (EC 5.1.3.23, UDP-GlcNAc3NAcA 2-epimerase, UDP-alpha-D-GlcNAc3NAcA 2-epimerase, 2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid 2-epimerase, WbpI, WlbD) is an enzyme with systematic name 2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate 2-epimerase.[1][2][3] This enzyme catalyses the following chemical reaction

UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate
UDP-2,3-diacetamido-2,3-dideoxyglucuronic acid 2-epimerase
Identifiers
EC no.5.1.3.23
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

This enzyme participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA.

References

  1. Westman EL, McNally DJ, Rejzek M, Miller WL, Kannathasan VS, Preston A, Maskell DJ, Field RA, Brisson JR, Lam JS (July 2007). "Identification and biochemical characterization of two novel UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid 2-epimerases from respiratory pathogens". The Biochemical Journal. 405 (1): 123–30. doi:10.1042/BJ20070017. PMC 1925246. PMID 17346239.
  2. Westman, E.L.; McNally, D.J.; Rejzek, M.; Miller, W.L.; Kannathasan, V.S.; Preston, A.; Maskell, D.J.; Field, R.A.; Brisson, J.R.; Lam, J.S. (2007). "Erratum report: Identification and biochemical characterization of two novel UDP-2,3-diacetamido-2,3-dideoxy-α-D-glucuronic acid 2-epimerases from respiratory pathogens". Biochem. J. 405: 625. doi:10.1042/BJ4050625v.
  3. Sri Kannathasan V, Staines AG, Dong CJ, Field RA, Preston AG, Maskell DJ, Naismith JH (September 2001). "Overexpression, purification, crystallization and data collection on the Bordetella pertussis wlbD gene product, a putative UDP-GlcNAc 2'-epimerase". Acta Crystallographica Section D. 57 (Pt 9): 1310–2. doi:10.1107/s0907444901010885. PMID 11526328.
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