UNC5A

UNC5A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4V2A
Identifiers
Aliases	UNC5A, UNC5H1, unc-5 netrin receptor A
External IDs	OMIM: 607869 MGI: 894682 HomoloGene: 41474 GeneCards: UNC5A
Gene location (Human)
Chr.	Chromosome 5 (human)[1]
End	176,880,898 bp[1]
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)[2]
End	55,153,831 bp[2]
RNA expression pattern
	Top expressed in
	endothelial cell; ; middle temporal gyrus; ; Brodmann area 23; ; prefrontal cortex; ; superior frontal gyrus; ; Brodmann area 9; ; postcentral gyrus; ; cingulate gyrus; ; ganglionic eminence; ; entorhinal cortex;
	Top expressed in
	secondary oocyte; ; superior frontal gyrus; ; hippocampus proper; ; humerus; ; Anterior olfactory nucleus; ; cerebellar cortex; ; Meckel's cartilage; ; lateral part of occipital bone; ; rib; ; lesser wing of sphenoid bone;
	More reference expression data
	n/a
Gene ontology
Molecular function	netrin receptor activity;
Cellular component	intrinsic component of plasma membrane; integral component of membrane; neuronal cell body membrane; membrane raft; plasma membrane; cell projection; neuron projection membrane; membrane;
Biological process	multicellular organism development; neuron projection development; signal transduction; anterior/posterior axon guidance; axon guidance; apoptotic process; netrin-activated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	90249
	107448
	ENSG00000113763
	ENSMUSG00000025876
	Q6ZN44
	Q8K1S4
	NM_133369
	NM_153131; NM_001311128
	NP_588610
	NP_001298057; NP_694771
	Wikidata
View/Edit Human	View/Edit Mouse

Netrin receptor UNC5A is a protein that in humans is encoded by the UNC5A gene.[5]

UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM][5]

Interactions

UNC5A has been shown to interact with MAGED1.[6]

References

GRCh38: Ensembl release 89: ENSG00000113763 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000025876 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: UNC5A unc-5 homolog A (C. elegans)".
Williams ME, Strickland P, Watanabe K, Hinck L (May 2003). "UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE". The Journal of Biological Chemistry. 278 (19): 17483–90. doi:10.1074/jbc.M300415200. PMID 12598531.

Arakawa H (December 2004). "Netrin-1 and its receptors in tumorigenesis". Nature Reviews. Cancer. 4 (12): 978–87. doi:10.1038/nrc1504. PMID 15573119. S2CID 867903.
Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Nagase T, Kikuno R, Ohara O (December 2001). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Research. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.
Williams ME, Strickland P, Watanabe K, Hinck L (May 2003). "UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE". The Journal of Biological Chemistry. 278 (19): 17483–90. doi:10.1074/jbc.M300415200. PMID 12598531.
Tanikawa C, Matsuda K, Fukuda S, Nakamura Y, Arakawa H (March 2003). "p53RDL1 regulates p53-dependent apoptosis". Nature Cell Biology. 5 (3): 216–23. doi:10.1038/ncb943. PMID 12598906. S2CID 7017409.
Thiebault K, Mazelin L, Pays L, Llambi F, Joly MO, Scoazec JY, et al. (April 2003). "The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment". Proceedings of the National Academy of Sciences of the United States of America. 100 (7): 4173–8. Bibcode:2003PNAS..100.4173T. doi:10.1073/pnas.0738063100. PMC 153067. PMID 12655055.
Geisbrecht BV, Dowd KA, Barfield RW, Longo PA, Leahy DJ (August 2003). "Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin". The Journal of Biological Chemistry. 278 (35): 32561–8. doi:10.1074/jbc.M302943200. PMID 12810718.
Llambi F, Lourenço FC, Gozuacik D, Guix C, Pays L, Del Rio G, et al. (March 2005). "The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase". The EMBO Journal. 24 (6): 1192–201. doi:10.1038/sj.emboj.7600584. PMC 556396. PMID 15729359.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113763 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025876 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: UNC5A unc-5 homolog A (C. elegans)".

[pmid12598531-6] Williams ME, Strickland P, Watanabe K, Hinck L (May 2003). "UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE". The Journal of Biological Chemistry. 278 (19): 17483–90. doi:10.1074/jbc.M300415200. PMID 12598531.

UNC5A

Interactions

References

Further reading