Uroplakin-1b

Uroplakin-1b (UP1b), is a protein which in humans is encoded by the UPK1B gene.[5][6][7]

UPK1B
Identifiers
AliasesUPK1B, TSPAN20, UPIB, UPK1, uroplakin 1B
External IDsOMIM: 602380 MGI: 98912 HomoloGene: 5065 GeneCards: UPK1B
Orthologs
SpeciesHumanMouse
Entrez

7348

22268

Ensembl

ENSG00000114638

ENSMUSG00000049436

UniProt

O75841

Q9Z2C6

RefSeq (mRNA)

NM_006952

NM_178924

RefSeq (protein)

NP_008883

NP_849255

Location (UCSC)Chr 3: 119.17 – 119.21 MbChr 16: 38.59 – 38.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. These proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The AUM is believed to be involved in strengthening the cells that line the bladder, and in enhancing the inner bladder membrane's ability to stretch, thus preventing these cells from rupturing during bladder distension. The use of alternate polyadenylation sites has been found for this gene.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000114638 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000049436 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: UPK1B uroplakin 1B".
  6. Lobban ED, Smith BA, Hall GD, Harnden P, Roberts P, Selby PJ, Trejdosiewicz LK, Southgate J (December 1998). "Uroplakin gene expression by normal and neoplastic human urothelium". Am. J. Pathol. 153 (6): 1957–67. doi:10.1016/S0002-9440(10)65709-4. PMC 1866332. PMID 9846985. Archived from the original on 2010-09-10. Retrieved 2009-01-26.
  7. Finch JL, Miller J, Aspinall JO, Cowled PA (February 1999). "Cloning of the human uroplakin 1B cDNA and analysis of its expression in urothelial-tumor cell lines and bladder-carcinoma tissue". Int. J. Cancer. 80 (4): 533–8. doi:10.1002/(SICI)1097-0215(19990209)80:4<533::AID-IJC9>3.0.CO;2-5. PMID 9935153.

Further reading


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