USP1

Ubiquitin carboxyl-terminal hydrolase 1 is an enzyme that in humans is encoded by the USP1 gene.[5][6]

USP1
Identifiers
AliasesUSP1, UBP, ubiquitin specific peptidase 1
External IDsOMIM: 603478 MGI: 2385198 HomoloGene: 2528 GeneCards: USP1
Orthologs
SpeciesHumanMouse
Entrez

7398

230484

Ensembl

ENSG00000162607

ENSMUSG00000028560

UniProt

O94782

Q8BJQ2

RefSeq (mRNA)

NM_003368
NM_001017415
NM_001017416

NM_001301414
NM_146144
NM_001356424

RefSeq (protein)

NP_001017415
NP_001017416
NP_003359

NP_001288343
NP_666256
NP_001343353

Location (UCSC)Chr 1: 62.44 – 62.45 MbChr 4: 98.81 – 98.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins.

The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000162607 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028560 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Puente XS, Sánchez LM, Overall CM, López-Otín C (July 2003). "Human and mouse proteases: a comparative genomic approach". Nature Reviews. Genetics. 4 (7): 544–558. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
  6. "Entrez Gene: USP1 ubiquitin specific peptidase 1".

Further reading


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