UVRAG

UV radiation resistance-associated gene protein is a protein that in humans is encoded by the UVRAG gene.[5][6]

UVRAG
Identifiers
AliasesUVRAG, DHTX, VPS38, p63, UV radiation resistance associated
External IDsOMIM: 602493 MGI: 1925860 HomoloGene: 31150 GeneCards: UVRAG
Orthologs
SpeciesHumanMouse
Entrez

7405

78610

Ensembl

ENSG00000198382

ENSMUSG00000035354

UniProt

Q9P2Y5

Q8K245

RefSeq (mRNA)

NM_003369

NM_178635

RefSeq (protein)

NP_003360

NP_848750

Location (UCSC)Chr 11: 75.82 – 76.14 MbChr 7: 98.53 – 98.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells.

Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000198382 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000035354 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Perelman B, Dafni N, Naiman T, Eli D, Yaakov M, Feng TL, Sinha S, Weber G, Khodaei S, Sancar A, Dotan I, Canaani D (Jul 1997). "Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus". Genomics. 41 (3): 397–405. doi:10.1006/geno.1997.4623. PMID 9169138.
  6. "Entrez Gene: UVRAG UV radiation resistance associated gene".

Further reading


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