Urea carboxylase

In enzymology, a urea carboxylase (EC 6.3.4.6) is an enzyme that catalyzes the chemical reaction

ATP + urea + HCO3- ADP + phosphate + urea-1-carboxylate
urea carboxylase
Identifiers
EC no.6.3.4.6
CAS no.9058-98-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

The 3 substrates of this enzyme are ATP, urea, and HCO3-, whereas its 3 products are ADP, phosphate, and urea-1-carboxylate (allophanate).

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is urea:carbon-dioxide ligase (ADP-forming). This enzyme participates in urea cycle and metabolism of amino groups. It employs one cofactor, biotin.

See also

References

    • Roon RJ; Levenberg B (1970). "[37a] ATP: Urea amidolyase (ADP) (Candida utilis)". Metabolism of Amino Acids and Amines Part A. pp. 317–324. doi:10.1016/0076-6879(71)17204-7. ISBN 9780121818746. {{cite book}}: |journal= ignored (help)
    • Roon RJ, Levenberg B (1972). "Urea amidolyase. I. Properties of the enzyme from Candida utilis". J. Biol. Chem. 247 (13): 4107–13. PMID 4556303.
    • Sumrada RA, Cooper TG (1982). "Urea carboxylase and allophanate hydrolase are components of a multifunctional protein in yeast". J. Biol. Chem. 257 (15): 9119–27. PMID 6124544.
    • Kanamori T, Kanou N, Atomi H, Imanaka T (2004). "Enzymatic characterization of a prokaryotic urea carboxylase". J. Bacteriol. 186 (9): 2532–9. doi:10.1128/JB.186.9.2532-2539.2004. PMC 387783. PMID 15090492.


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