VAT1

Synaptic vesicle membrane protein VAT-1 homolog is a protein that in humans is encoded by the VAT1 gene.[5][6][7]

VAT1
Identifiers
AliasesVAT1, VATI, vesicle amine transport 1
External IDsOMIM: 604631 MGI: 1349450 HomoloGene: 36200 GeneCards: VAT1
Orthologs
SpeciesHumanMouse
Entrez

10493

26949

Ensembl

ENSG00000108828

ENSMUSG00000034993

UniProt

Q99536

Q62465

RefSeq (mRNA)

NM_006373

NM_012037

RefSeq (protein)

NP_006364
NP_006364.2

NP_036167

Location (UCSC)Chr 17: 43.01 – 43.03 MbChr 11: 101.35 – 101.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Synaptic vesicles are responsible for regulating the storage and release of neurotransmitters in the nerve terminal. The protein encoded by this gene is an abundant integral membrane protein of cholinergic synaptic vesicles and is thought to be involved in vesicular transport. It belongs to the quinone oxidoreductase subfamily of zinc-containing alcohol dehydrogenase proteins.[7]

In melanocytic cells VAT1 gene expression may be regulated by MITF.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000108828 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000034993 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Friedman LS, Ostermeyer EA, Lynch ED, Welcsh P, Szabo CI, Meza JE, Anderson LA, Dowd P, Lee MK, Rowell SE, et al. (Jul 1995). "22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors". Genomics. 25 (1): 256–63. doi:10.1016/0888-7543(95)80133-7. PMID 7774926.
  6. Smith TM, Lee MK, Szabo CI, Jerome N, McEuen M, Taylor M, Hood L, King MC (Feb 1997). "Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1". Genome Res. 6 (11): 1029–49. doi:10.1101/gr.6.11.1029. PMID 8938427.
  7. "Entrez Gene: VAT1 vesicle amine transport protein 1 homolog (T. californica)".
  8. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.

Further reading


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