VAV3

Guanine nucleotide exchange factor VAV3 is a protein that in humans is encoded by the VAV3 gene.[5]

VAV3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesVAV3, vav guanine nucleotide exchange factor 3
External IDsOMIM: 605541 MGI: 1888518 HomoloGene: 38143 GeneCards: VAV3
Orthologs
SpeciesHumanMouse
Entrez

10451

57257

Ensembl

ENSG00000134215

ENSMUSG00000033721

UniProt

Q9UKW4

Q9R0C8

RefSeq (mRNA)

NM_001079874
NM_006113

NM_020505
NM_146139
NM_001378987

RefSeq (protein)

NP_001073343
NP_006104

NP_065251
NP_666251
NP_001365916

Location (UCSC)Chr 1: 107.57 – 107.97 MbChr 3: 109.25 – 109.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[5]

Interactions

VAV3 has been shown to interact with Grb2.[6][7]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000134215 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000033721 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: VAV3 vav 3 oncogene".
  6. Blagoev, Blagoy; Kratchmarova Irina; Ong Shao-En; Nielsen Mogens; Foster Leonard J; Mann Matthias (March 2003). "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling". Nat. Biotechnol. 21 (3): 315–318. doi:10.1038/nbt790. ISSN 1087-0156. PMID 12577067. S2CID 26838266.
  7. Zeng, L; Sachdev P; Yan L; Chan J L; Trenkle T; McClelland M; Welsh J; Wang L H (December 2000). "Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation". Mol. Cell. Biol. 20 (24): 9212–9224. doi:10.1128/MCB.20.24.9212-9224.2000. ISSN 0270-7306. PMC 102179. PMID 11094073.

Further reading


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