PARP4

Poly [ADP-ribose] polymerase 4 is an enzyme that in humans is encoded by the PARP4 gene.[5][6]

PARP4
Identifiers
AliasesPARP4, ADPRTL1, ARTD4, PARP-4, PARPL, PH5P, VAULT3, VPARP, VWA5C, p193, poly(ADP-ribose) polymerase family member 4
External IDsOMIM: 607519 MGI: 2685589 HomoloGene: 124423 GeneCards: PARP4
Orthologs
SpeciesHumanMouse
Entrez

143

328417

Ensembl

ENSG00000102699

ENSMUSG00000054509

UniProt

Q9UKK3

E9PYK3

RefSeq (mRNA)

NM_006437

NM_001145978

RefSeq (protein)

NP_006428

NP_001139450

Location (UCSC)Chr 13: 24.42 – 24.51 MbChr 14: 56.81 – 56.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.[6]

Interactions

PARP4 has been shown to interact with Major vault protein.[7][8]

References

  1. GRCh38: Ensembl release 89: ENSG00000102699 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000054509 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Still IH, Vince P, Cowell JK (Mar 2000). "Identification of a novel gene (ADPRTL1) encoding a potential Poly(ADP-ribosyl)transferase protein". Genomics. 62 (3): 533–6. doi:10.1006/geno.1999.6024. PMID 10644454.
  6. "Entrez Gene: PARP4 poly (ADP-ribose) polymerase family, member 4".
  7. van Zon, Arend; Mossink Marieke H; Schoester Martijn; Scheffer George L; Scheper Rik J; Sonneveld Pieter; Wiemer Erik A C (Mar 2002). "Structural domains of vault proteins: a role for the coiled coil domain in vault assembly". Biochem. Biophys. Res. Commun. 291 (3): 535–41. doi:10.1006/bbrc.2002.6472. ISSN 0006-291X. PMID 11855821.
  8. Kickhoefer, V A; Siva A C; Kedersha N L; Inman E M; Ruland C; Streuli M; Rome L H (Sep 1999). "The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase". J. Cell Biol. 146 (5): 917–28. doi:10.1083/jcb.146.5.917. ISSN 0021-9525. PMC 2169495. PMID 10477748.

Further reading

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