VPS11

Vacuolar protein sorting-associated protein 11 homolog is a protein that in humans is encoded by the VPS11 gene.[5]

VPS11
Identifiers
AliasesVPS11, END1, PEP5, RNF108, hHLD12, CORVET/HOPS core subunit, VPS11 core subunit of CORVET and HOPS complexes
External IDsOMIM: 608549 MGI: 1918982 HomoloGene: 6673 GeneCards: VPS11
Orthologs
SpeciesHumanMouse
Entrez

55823

71732

Ensembl

ENSG00000160695
ENSG00000280616

ENSMUSG00000032127

UniProt

Q9H270

Q91W86

RefSeq (mRNA)

NM_001290185
NM_021729

NM_027889
NM_001357393

RefSeq (protein)

NP_082165
NP_001344322

Location (UCSC)Chr 11: 119.07 – 119.08 MbChr 9: 44.26 – 44.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.[5]

Interactions

VPS11 has been shown to interact with VPS18,[6] VPS33A[6] and STX7.[6]

References

  1. ENSG00000280616 GRCh38: Ensembl release 89: ENSG00000160695, ENSG00000280616 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000032127 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae)".
  6. Kim BY, Krämer H, Yamamoto A, Kominami E, Kohsaka S, Akazawa C (August 2001). "Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7". J. Biol. Chem. 276 (31): 29393–402. doi:10.1074/jbc.M101778200. PMID 11382755.

Further reading


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