VPS36

VPS36
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HTH, 2ZME, 3CUQ
Identifiers
Aliases	VPS36, C13orf9, EAP45, CGI-145, vacuolar protein sorting 36 homolog
External IDs	OMIM: 610903 MGI: 1917410 HomoloGene: 9374 GeneCards: VPS36
Gene location (Human)
Chr.	Chromosome 13 (human)[1]
End	52,450,634 bp[1]
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)[2]
End	22,710,859 bp[2]
RNA expression pattern
	Top expressed in
	pancreatic epithelial cell; ; pancreatic ductal cell; ; tibialis anterior muscle; ; endothelial cell; ; skin of abdomen; ; deltoid muscle; ; Brodmann area 23; ; rectum; ; Achilles tendon; ; cerebellar vermis;
	Top expressed in
	trigeminal ganglion; ; urothelium; ; Paneth cell; ; hair follicle; ; ureter; ; medullary collecting duct; ; endocardial cushion; ; spermatid; ; otic placode; ; atrioventricular valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphatidylinositol-3-phosphate binding; protein C-terminus binding; ubiquitin binding; protein binding; lipid binding;
Cellular component	cytoplasm; cytosol; late endosome; membrane; late endosome membrane; lysosome; extracellular exosome; nucleus; endosome; ESCRT II complex;
Biological process	regulation of transcription, DNA-templated; multivesicular body assembly; transcription, DNA-templated; endosomal transport; protein transport; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; macroautophagy; transport; endosome transport via multivesicular body sorting pathway;
	Sources:Amigo / QuickGO
Orthologs
	51028
	70160
	ENSG00000136100
	ENSMUSG00000031479
	Q86VN1
	Q91XD6
	NM_016075; NM_001282168; NM_001282169
	NM_027338; NM_001368379
	NP_001269097; NP_001269098; NP_057159
	NP_081614; NP_001355308
	Wikidata
View/Edit Human	View/Edit Mouse

Vacuolar protein-sorting-associated protein 36 is a protein that in humans is encoded by the VPS36 gene.[5][6][7]

References

GRCh38: Ensembl release 89: ENSG00000136100 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000031479 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Kamura T, Burian D, Khalili H, Schmidt SL, Sato S, Liu WJ, Conrad MN, Conaway RC, Conaway JW, Shilatifard A (May 2001). "Cloning and characterization of ELL-associated proteins EAP45 and EAP20. a role for yeast EAP-like proteins in regulation of gene expression by glucose". J Biol Chem. 276 (19): 16528–33. doi:10.1074/jbc.M010142200. PMID 11278625.
Slagsvold T, Aasland R, Hirano S, Bache KG, Raiborg C, Trambaiolo D, Wakatsuki S, Stenmark H (May 2005). "Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide-interacting GLUE domain". J Biol Chem. 280 (20): 19600–6. doi:10.1074/jbc.M501510200. PMID 15755741.
"Entrez Gene: VPS36 vacuolar protein sorting 36 homolog (S. cerevisiae)".

Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
von Schwedler UK, Stuchell M, Müller B, et al. (2003). "The protein network of HIV budding". Cell. 114 (6): 701–13. doi:10.1016/S0092-8674(03)00714-1. PMID 14505570.
Martin-Serrano J, Yarovoy A, Perez-Caballero D, et al. (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. doi:10.1073/pnas.2133846100. PMC 218772. PMID 14519844.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Bowers K, Piper SC, Edeling MA, et al. (2006). "Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII". J. Biol. Chem. 281 (8): 5094–105. doi:10.1074/jbc.M508632200. PMID 16371348.
Alam SL, Langelier C, Whitby FG, et al. (2007). "Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain". Nat. Struct. Mol. Biol. 13 (11): 1029–30. doi:10.1038/nsmb1160. PMID 17057716. S2CID 41152121.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000136100 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031479 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11278625-5] Kamura T, Burian D, Khalili H, Schmidt SL, Sato S, Liu WJ, Conrad MN, Conaway RC, Conaway JW, Shilatifard A (May 2001). "Cloning and characterization of ELL-associated proteins EAP45 and EAP20. a role for yeast EAP-like proteins in regulation of gene expression by glucose". J Biol Chem. 276 (19): 16528–33. doi:10.1074/jbc.M010142200. PMID 11278625.

[pmid15755741-6] Slagsvold T, Aasland R, Hirano S, Bache KG, Raiborg C, Trambaiolo D, Wakatsuki S, Stenmark H (May 2005). "Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide-interacting GLUE domain". J Biol Chem. 280 (20): 19600–6. doi:10.1074/jbc.M501510200. PMID 15755741.

[entrez-7] "Entrez Gene: VPS36 vacuolar protein sorting 36 homolog (S. cerevisiae)".

VPS36

References

Further reading