VPS52

VPS52
Identifiers
Aliases	VPS52, ARE1, SAC2, SACM2L, dJ1033B10.5, GARP complex subunit, VPS52 subunit of GARP complex
External IDs	OMIM: 603443 MGI: 1330304 HomoloGene: 5756 GeneCards: VPS52
Gene location (Human)
Chr.	Chromosome 6 (human)[1]
End	33,272,047 bp[1]
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)[2]
End	34,186,009 bp[2]
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; right uterine tube; ; pituitary gland; ; left lobe of thyroid gland; ; spleen; ; anterior pituitary; ; fundus; ; skin of abdomen; ; body of pancreas; ; tibial nerve;
	Top expressed in
	superior frontal gyrus; ; lip; ; spermatocyte; ; yolk sac; ; cerebellar cortex; ; esophagus; ; neural tube; ; entorhinal cortex; ; spermatid; ; seminiferous tubule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	syntaxin binding; protein binding;
Cellular component	perinuclear region of cytoplasm; recycling endosome; EARP complex; endosome; Golgi apparatus; endosome membrane; membrane; trans-Golgi network membrane; GARP complex; cytosol;
Biological process	protein transport; ectodermal cell differentiation; embryonic ectodermal digestive tract development; endocytic recycling; lysosomal transport; Golgi to vacuole transport; retrograde transport, endosome to Golgi;
	Sources:Amigo / QuickGO
Orthologs
	6293
	224705
ENSG00000236014; ENSG00000206286; ENSG00000223501; ENSG00000224455; ENSG00000225590;
	ENSG00000223618; ENSG00000228425
	ENSMUSG00000024319
	Q8N1B4
	Q8C754
	NM_001289174; NM_001289175; NM_001289176; NM_022553
	NM_172620; NM_001357329; NM_001357330; NM_001379410; NM_001379411
	NP_001276103; NP_001276104; NP_001276105; NP_072047
	NP_766208; NP_001344258; NP_001344259; NP_001366339; NP_001366340
	Wikidata
View/Edit Human	View/Edit Mouse

Vacuolar protein sorting-associated protein 52 homolog is a protein that in humans is encoded by the VPS52 gene.[5][6]

This gene encodes a protein that is similar to the yeast suppressor of actin mutations 2 gene. The yeast protein forms a subunit of the tetrameric Golgi-associated retrograde protein complex that is involved in vesicle trafficking from both early and late endosomes, back to the trans-Golgi network. This gene is located on chromosome 6 in a head-to-head orientation with the gene encoding ribosomal protein S18.[6]

References

ENSG00000206286, ENSG00000223501, ENSG00000224455, ENSG00000225590, ENSG00000223618, ENSG00000228425 GRCh38: Ensembl release 89: ENSG00000236014, ENSG00000206286, ENSG00000223501, ENSG00000224455, ENSG00000225590, ENSG00000223618, ENSG00000228425 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024319 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Walter L, Gunther E (Dec 1998). "Identification of a novel highly conserved gene in the centromeric part of the major histocompatibility complex". Genomics. 52 (3): 298–304. doi:10.1006/geno.1998.5463. PMID 9790748.
"Entrez Gene: VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae)".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Stephens R, Horton R, Humphray S, et al. (1999). "Gene organisation, sequence variation and isochore structure at the centromeric boundary of the human MHC". J. Mol. Biol. 291 (4): 789–99. doi:10.1006/jmbi.1999.3004. PMID 10452889.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Liewen H, Meinhold-Heerlein I, Oliveira V, et al. (2005). "Characterization of the human GARP (Golgi associated retrograde protein) complex". Exp. Cell Res. 306 (1): 24–34. doi:10.1016/j.yexcr.2005.01.022. PMID 15878329.

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[refGRCh38Ensembl-1] ENSG00000206286, ENSG00000223501, ENSG00000224455, ENSG00000225590, ENSG00000223618, ENSG00000228425 GRCh38: Ensembl release 89: ENSG00000236014, ENSG00000206286, ENSG00000223501, ENSG00000224455, ENSG00000225590, ENSG00000223618, ENSG00000228425 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024319 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9790748-5] Walter L, Gunther E (Dec 1998). "Identification of a novel highly conserved gene in the centromeric part of the major histocompatibility complex". Genomics. 52 (3): 298–304. doi:10.1006/geno.1998.5463. PMID 9790748.

[entrez-6] "Entrez Gene: VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae)".

VPS52

References

Further reading