V-set and immunoglobulin domain containing 4

VSIG4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ICC, 2ICE, 2ICF
Identifiers
Aliases	VSIG4, CRIg, Z39IG, V-set and immunoglobulin domain containing 4
External IDs	OMIM: 300353 MGI: 2679720 HomoloGene: 48515 GeneCards: VSIG4
Gene location (Human)
Chr.	X chromosome (human)[1]
End	66,040,125 bp[1]
Gene location (Mouse)
Chr.	X chromosome (mouse)[2]
End	95,337,044 bp[2]
RNA expression pattern
	Top expressed in
	right lung; ; lower lobe of lung; ; gastric mucosa; ; right coronary artery; ; synovial membrane; ; upper lobe of lung; ; upper lobe of left lung; ; synovial joint; ; visceral pleura; ; placenta;
	Top expressed in
	ankle; ; liver; ; left lobe of liver; ; myocardium of ventricle; ; aorta; ; white adipose tissue; ; esophagus; ; skin of abdomen; ; spermatid; ; carotid body;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; complement component C3b binding;
Cellular component	integral component of membrane; membrane; protein-containing complex;
Biological process	innate immune response; complement activation, alternative pathway; immune system process; negative regulation of interleukin-2 production; negative regulation of T cell proliferation; negative regulation of macrophage activation; negative regulation of complement activation, alternative pathway;
	Sources:Amigo / QuickGO
Orthologs
	11326
	278180
	ENSG00000155659
	ENSMUSG00000044206
	Q9Y279
	F6TUL9
	NM_007268; NM_001100431; NM_001184830; NM_001184831; NM_001257403
	NM_177789
	NP_001093901; NP_001171759; NP_001171760; NP_001244332; NP_009199
	NP_808457
	Wikidata
View/Edit Human	View/Edit Mouse

V-set and immunoglobulin domain containing 4 is a protein that in humans is encoded by the VSIG4 gene.[5]

Function

This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants.

References

GRCh38: Ensembl release 89: ENSG00000155659 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000044206 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: V-set and immunoglobulin domain containing 4". Retrieved 2016-06-13.

V-set and immunoglobulin domain containing 4

Function

References

Further reading