Vac7

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Structures	Swiss-model
Domains	InterPro

Vacuolar segregation protein 7
Vacuolar segregation protein 7
Identifiers
Organism	S. cerevisiae S288c
Symbol	VAC7
Entrez	855673
RefSeq (mRNA)	NM_001182893
RefSeq (Prot)	NP_014344
UniProt	P53950
Other data
Chromosome	XIV: 0.53 - 0.53 Mb
Structures
Search for
Structures	Swiss-model
Domains	InterPro

Vacuolar segregation protein 7 is a protein that in yeast is encoded by the VAC7 gene. VAC7 is a component of the PI(3,5)P2 regulatory complex, composed of ATG18, FIG4, FAB1, VAC14 and VAC7.

Function

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). VAC7 activates FAB1 kinase for example during hyperosmotic shock and can elevate levels of PtdIns(3,5)P2 in the absence of VAC14 and FIG4. VAC7 is directly involved in vacuolar membrane scission and is required for normal vacuole acidification, inheritance and morphology.[1][2][3][4][5]

References

UniProt P53950
Bonangelino CJ, Catlett NL, Weisman LS (December 1997). "Vac7p, a novel vacuolar protein, is required for normal vacuole inheritance and morphology". Mol. Cell. Biol. 17 (12): 6847–58. doi:10.1128/MCB.17.12.6847. PMC 232541. PMID 9372916.
Gary JD, Sato TK, Stefan CJ, Bonangelino CJ, Weisman LS, Emr SD (April 2002). "Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member". Mol. Biol. Cell. 13 (4): 1238–51. doi:10.1091/mbc.01-10-0498. PMC 102265. PMID 11950935.
Duex JE, Tang F, Weisman LS (February 2006). "The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover". J. Cell Biol. 172 (5): 693–704. doi:10.1083/jcb.200512105. PMC 2063702. PMID 16492811.
Jin N, Chow CY, Liu L, Zolov SN, Bronson R, Davisson M, Petersen JL, Zhang Y, Park S, Duex JE, Goldowitz D, Meisler MH, Weisman LS (December 2008). "VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse" (PDF). EMBO J. 27 (24): 3221–34. doi:10.1038/emboj.2008.248. PMC 2600653. PMID 19037259.

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[UniProt-1] UniProt P53950

[pmid9372916-2] Bonangelino CJ, Catlett NL, Weisman LS (December 1997). "Vac7p, a novel vacuolar protein, is required for normal vacuole inheritance and morphology". Mol. Cell. Biol. 17 (12): 6847–58. doi:10.1128/MCB.17.12.6847. PMC 232541. PMID 9372916.

[pmid11950935-3] Gary JD, Sato TK, Stefan CJ, Bonangelino CJ, Weisman LS, Emr SD (April 2002). "Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member". Mol. Biol. Cell. 13 (4): 1238–51. doi:10.1091/mbc.01-10-0498. PMC 102265. PMID 11950935.

[pmid16492811-4] Duex JE, Tang F, Weisman LS (February 2006). "The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover". J. Cell Biol. 172 (5): 693–704. doi:10.1083/jcb.200512105. PMC 2063702. PMID 16492811.

[pmid19037259-5] Jin N, Chow CY, Liu L, Zolov SN, Bronson R, Davisson M, Petersen JL, Zhang Y, Park S, Duex JE, Goldowitz D, Meisler MH, Weisman LS (December 2008). "VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse" (PDF). EMBO J. 27 (24): 3221–34. doi:10.1038/emboj.2008.248. PMC 2600653. PMID 19037259.