Vaccinia immune globulin

Vaccinia immune globulin (VIG) is made from the pooled blood of individuals who have been inoculated with the smallpox vaccine. The antibodies these individuals developed in response to the smallpox vaccine are removed and purified. This results in VIG. It can be administered intravenously. It is used to treat individuals who have developed progressive vaccinia after smallpox vaccination.

It was also used along with cidofovir for the 2003 Midwest monkeypox outbreak as concomitant therapy to reduce the serious side effects of smallpox vaccine.[1][2] In addition, CDC states that use of VIGIV may be considered for postexposure prophylaxis of monkeypox in exposed individuals who cannot receive postexposure vaccination with smallpox vaccine because of severe T-cell function immunodeficiency.[3][4]

Adverse effects of smallpox vaccine

For a small percentage of the population, the smallpox vaccine either doesn't "take" or it produces adverse events. These include postvaccinial central nervous system disease, progressive vaccinia, eczema vaccinatum, accidental implantations, “generalized vaccinia,” and the common erythematous and/or urticarial rashes.[5][6][7][8]

Development of immune globulin

In the late 1940s, Dr. Henry Kempe suggested that the solution to the complications of the smallpox vaccine was to provide antibodies in the form of gamma globulin, a medical treatment known as Passive immunity.[9][10] Kempe noted that for some infants, the smallpox vaccine failed to "take." Kempe believed this failure might be due to the high levels of maternal antibodies to vaccinia in the infants' blood. It appeared to Kempe, that the presence of the antibodies blocked viral replication and therefore a transfusion of antibodies from people who were immune due to vaccination, would help those in whom vaccination had failed.[11]

Two intravenous formulations of VIG (VIGIV Cangene and VIGIV Dynport) have been licensed by the FDA for the management of patients with progressive vaccinia, eczema vaccinatum, severe generalized vaccinia, and extensive body surface involvement or periocular implantation following inadvertent inoculation.[12][13]

Cangene (a subsidiary of Emergent BioSolutions) brand-name VIGIV may be known to you by an alternate name: C-VIG; CNJ 016; NP 016 - Cangene; VIG; VIGIV - Emergent BioSolutions.[14] This type of medicine called an Antiserum has been used in many treatments successfully, and some research and clinical trials for its use treating Monkeypox has been completed.[15]

An initial post-marketing study was updated in 2021 to verify the clinical benefits of VIGIV (CNJ-016, Vaccinia Immune Globulin Intravenous (Human), sterile solution) in the resolution of complications resulting from Orthopoxvirus vaccination in eligible patients treated with VIGIV named Clinical Outcomes of VIGIV Treatment of Smallpox Vaccination Complications or Vaccinia Infection.[16]

Orthopoxvirus Vaccination

Vaccinia immune globulin intravenous (VIGIV) is recommended as the first line of therapy for treatment of adverse reactions resulting from continued vaccinia virus replication after vaccination using ACAM2000® or APSV.[17][18][19][20][21]

VIGIV is not commercially available but can be made available through the Strategic National Stockpile (SNS) for the treatment of smallpox vaccine complications in patients with serious clinical manifestations.

Other treatments are

The Orthopoxvirus (Smallpox) vaccine management guidelines are available from the Centers for Disease Control and Prevention.[22]

Literature such as Progressive Vaccinia: Case Description and Laboratory-Guided Therapy With Vaccinia Immune Globulin, ST-246®, and CMX001 explains in clinical terms to the layperson (non-medical staff, or the patient and their families) what happens during this treatment when they are sick.[23]

HIV and AIDS positive people are at risk of developing reactions and side-effects when they have Orthopoxvirus. Literature such as Progressive Vaccinia Acquired through Zoonotic Transmission in a Patient with HIV/AIDS explains again in clinical terms why patients with immunodeficiency (from HIV infection, or from any other medical condition that effects your immune system) are at high risk.[24] Likewise, infants (and by extension during pregnancy), and the elderly with pre-existing medical conditions are more likely to have more serious reactions.[25] If you have been taking serum antibodies for immunodeficiency, you should note this medicine VIGIV has a different name, and has similarities but is for a specific case (if you get necrosis from a smallpox vaccine) rather than a generalized treatment for immunodeficiency.[26] These (IgG, IgA, IgM, IgD, and IgE, IgG) previously have been researched for use with Modified Vaccinia virus Ankara®, more so than VIGIV as a treatment for Monkeypox.[27][28]

See also

References

  1. "CDC Smallpox | Investigational Vaccinia Immune Globulin (VIG) Information". Bt.cdc.gov. Retrieved 2013-06-16.
  2. Wharton, M; Strikas, RA; Harpaz, R; Rotz, LD; Schwartz, B; Casey, CG; Pearson, ML; Anderson, LJ (4 April 2003). "Recommendations for using smallpox vaccine in a pre-event vaccination program. Supplemental recommendations of the Advisory Committee on Immunization Practices (ACIP) and the Healthcare Infection Control Practices Advisory Committee (HICPAC)". MMWR. Recommendations and Reports. 52 (RR-7): 1–16. PMID 12710832.
  3. "Vaccinia Immune Globulin IV Monograph for Professionals". Drugs.com.
  4. "Monkeypox | Agent Fact Sheet". 17 August 2023.
  5. Lane, J.Michael; Goldstein, Joel (July 2003). "Adverse events occurring after smallpox vaccination". Seminars in Pediatric Infectious Diseases. 14 (3): 189–195. doi:10.1016/s1045-1870(03)00032-3. PMID 12913830.
  6. Frelinger, JA; Garba, ML (29 August 2002). "Responses to smallpox vaccine". The New England Journal of Medicine. 347 (9): 689–90, author reply 689-90. doi:10.1056/NEJM200208293470913. PMID 12201305.
  7. Møller-Larsen, A; Haahr, S (January 1978). "Humoral and cell-mediated immune responses in humans before and after revaccination with vaccinia virus". Infection and Immunity. 19 (1): 34–39. doi:10.1128/iai.19.1.34-39.1978. PMC 414044. PMID 624594.
  8. Cohen, Jon (2 November 2001). "Smallpox Vaccinations: How Much Protection Remains?". Science. 294 (5544): 985. doi:10.1126/science.294.5544.985. PMID 11691969. S2CID 28270372.
  9. "Vaccinia immune globulin definition - Medical Dictionary definitions of popular medical terms easily defined on MedTerms". Medterms.com. 2012-06-14. Retrieved 2013-06-16.
  10. "CDC Smallpox | Medical Management of Smallpox (Vaccinia) Vaccine Adverse Reactions (Info for Clinicians and Public Health Professionals)". Bt.cdc.gov. Retrieved 2013-06-16.
  11. Bray, M. (15 September 2004). "Henry Kempe and the Birth of Vaccinia Immune Globulin". Clinical Infectious Diseases. 39 (6): 767–769. doi:10.1086/423005. PMID 15472805.
  12. Wittek, Riccardo (1 May 2006). "Vaccinia immune globulin: current policies, preparedness, and product safety and efficacy". International Journal of Infectious Diseases. 10 (3): 193–201. doi:10.1016/j.ijid.2005.12.001. PMID 16564720.
  13. "DynPort Vaccine Company | GDIT".
  14. "DailyMed - CNJ-016 (Vaccinia immune globulin- human injection".
  15. Leendertz, Siv; Stern, Daniel; Theophil, Dennis; Anoh, Etile; Mossoun, Arsène; Schubert, Grit; Wiersma, Lidewij; Akoua-Koffi, Chantal; Couacy-Hymann, Emmanuel; Muyembe-Tamfum, Jean-Jacques; Karhemere, Stomy; Pauly, Maude; Schrick, Livia; Leendertz, Fabian; Nitsche, Andreas (29 September 2017). "A Cross-Sectional Serosurvey of Anti-Orthopoxvirus Antibodies in Central and Western Africa". Viruses. 9 (10): 278. doi:10.3390/v9100278. PMC 5691630. PMID 28961172.
  16. Clinical trial number NCT01374984 for "VA-005 Clinical Outcomes of VIGIV Treatment of Smallpox Vaccination Complications or Vaccinia Infection" at ClinicalTrials.gov
  17. "Medical Management of Adverse Reactions to Vaccinia Virus Vaccination | Smallpox | CDC". 2 November 2021.
  18. "Progressive Vaccinia - an overview | ScienceDirect Topics".
  19. "VIGIV (Vaccinia immune globulin intravenous) dosing, indications, interactions, adverse effects, and more".
  20. Eggleton, J. S.; Nagalli, S. (2022). "Highly Active Antiretroviral Therapy (HAART)". StatPearls. StatPearls. PMID 32119420.
  21. Izzedine, Hassane; Launay-Vacher, Vincent; Baumelou, Alain; Deray, Gilbert (August 2004). "Antiretroviral and immunosuppressive drug-drug interactions: An update". Kidney International. 66 (2): 532–541. doi:10.1111/j.1523-1755.2004.00772.x. PMID 15253704.
  22. "Medical Management of Adverse Reactions to Vaccinia Virus Vaccination | Smallpox | CDC". 2 November 2021.
  23. Lederman, E. R.; Davidson, W.; Groff, H. L.; Smith, S. K.; Warkentien, T.; Li, Y.; Wilkins, K. A.; Karem, K. L.; Akondy, R. S.; Ahmed, R.; Frace, M.; Shieh, W.-J.; Zaki, S.; Hruby, D. E.; Painter, W. P.; Bergman, K. L.; Cohen, J. I.; Damon, I. K. (1 November 2012). "Progressive Vaccinia: Case Description and Laboratory-Guided Therapy With Vaccinia Immune Globulin, ST-246, and CMX001". Journal of Infectious Diseases. 206 (9): 1372–1385. doi:10.1093/infdis/jis510. PMC 3529603. PMID 22904336.
  24. Laiton-Donato, Katherine; Ávila-Robayo, Paola; Páez-Martinez, Andrés; Benjumea-Nieto, Paula; Usme-Ciro, José A.; Pinzón-Nariño, Nicole; Giraldo, Ivan; Torres-Castellanos, Diego; Nakazawa, Yoshinori; Patel, Nishi; Wilkins, Kimberly; Li, Yu; Davidson, Whitni; Burgado, Jillybeth; Satheshkumar, Panayampalli Subbian; Styczynski, Ashley; Mauldin, Matthew R.; Gracia-Romero, Martha; Petersen, Brett W. (March 2020). "Progressive Vaccinia Acquired through Zoonotic Transmission in a Patient with HIV/AIDS, Colombia". Emerging Infectious Diseases. 26 (3): 601–605. doi:10.3201/eid2603.191365. PMC 7045850. PMID 32091366.
  25. Bray, Mike; Wright, Mary E. (15 March 2003). "Progressive Vaccinia". Clinical Infectious Diseases. 36 (6): 766–774. doi:10.1086/374244. PMID 12627361.
  26. "Specific Antibody Deficiency | Immune Deficiency Foundation".
  27. Earl, Patricia L.; Americo, Jeffrey L.; Wyatt, Linda S.; Anne Eller, Leigh; Montefiori, David C.; Byrum, Russ; Piatak, Michael; Lifson, Jeffrey D.; Rao Amara, Rama; Robinson, Harriet L.; Huggins, John W.; Moss, Bernard (15 September 2007). "Recombinant modified vaccinia virus Ankara provides durable protection against disease caused by an immunodeficiency virus as well as long-term immunity to an orthopoxvirus in a non-human primate". Virology. 366 (1): 84–97. doi:10.1016/j.virol.2007.02.041. PMC 2077303. PMID 17499326.
  28. Berger, Melvin (1 May 2008). "Principles of and Advances in Immunoglobulin Replacement Therapy for Primary Immunodeficiency". Immunology and Allergy Clinics of North America. 28 (2): 413–437. doi:10.1016/j.iac.2008.01.008. PMC 7127239. PMID 18424340.
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